Details of the Drug-Related molecule(s) Interaction Atlas

Platinum IV complexe 1 Drug Info

PMID26394986-Compound-69

Cross-matching ID

TTD Drug ID

DM8OYI4

General Information of Drug (ID: DM8OYI4)

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Patented Agent(s)

Approved Drug(s)

Clinical Trial Drug(s)

Discontinued Drug(s)

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Drug(s) Targeting Signal transducer and activator of transcription 5 (STAT5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
PMID26394986-Compound-10	DMP8RQ4	N. A.	N. A.	Patented	[1]
PMID26394986-Compound-56	DMPNJ4X	N. A.	N. A.	Patented	[1]
Indirubin derivative 1	DMB8673	N. A.	N. A.	Patented	[1]
PMID26394986-Compound-57	DMILUT8	N. A.	N. A.	Patented	[1]
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Drug(s) Targeting Signal transducer and activator of transcription 3 (STAT3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Acitretin	DM8BKU9	Psoriasis vulgaris	EA90	Approved	[2]
Napabucasin	DMDZ6Q3	Colorectal cancer	2B91.Z	Phase 3	[3]
Golotimod	DMKZN3A	Immune System disease	4A01-4B41	Phase 2	[4]
NT219	DMOYS1N	Solid tumour/cancer	2A00-2F9Z	Phase 1/2	[5]
WP-1066	DMUGHWR	Recurrent glioblastoma	2A00.00	Phase 1/2	[3]
Atiprimod	DM84YEC	Multiple myeloma	2A83	Phase 1/2	[6]
OPB-31121	DM6VGO3	Hepatocellular carcinoma	2C12.02	Phase 1/2	[7]
IMX-110	DMNHZS4	Solid tumour/cancer	2A00-2F9Z	Phase 1/2	[3]
GLG-801	DMY1CP9	Chronic lymphocytic leukaemia	2A82.0	Phase 1/2	[3]
OPB-51602	DM760FA	Solid tumour/cancer	2A00-2F9Z	Phase 1	[8]
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⏷ Show the Full List of 10 Drug(s)

Drug(s) Targeting Signal transducer and activator of transcription 1 (STAT1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
PMID26394986-Compound-10	DMP8RQ4	N. A.	N. A.	Patented	[1]
Oxazole derivative 1	DM7Y2RL	N. A.	N. A.	Patented	[1]
Peptidomimetic analog 5	DMF0DE2	N. A.	N. A.	Patented	[1]
Peptide analog 8	DMFG7A8	N. A.	N. A.	Patented	[1]
AVT-02 UE	DM8NA4M	Skin infection	1F28-1G0Z	Discontinued in Phase 2	[9]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

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Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Signal transducer and activator of transcription 1 (STAT1)	TTN7R6K	STAT1_HUMAN	Inhibitor	[1]
Signal transducer and activator of transcription 3 (STAT3)	TTH8FZW	STAT3_HUMAN	Inhibitor	[1]
Signal transducer and activator of transcription 5 (STAT5)	TTLRFIH	STA5A_HUMAN; STA5B_HUMAN	Inhibitor	[1]

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References

1	A STAT inhibitor patent review: progress since 2011.Expert Opin Ther Pat. 2015;25(12):1397-421.
2	Effects of acitretin on the expression of signaling pathway-related genes in epidermal squamous-cell carcinoma cells. Zhonghua Zhong Liu Za Zhi. 2006 Jan;28(1):21-4.
3	Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
4	National Cancer Institute Drug Dictionary (drug id 617379).
5	Clinical pipeline report, company report or official report of Purple Biotech.
6	Emerging therapies for multiple myeloma. Expert Opin Emerg Drugs. 2009 Mar;14(1):99-127.
7	OPB-31121, a novel small molecular inhibitor, disrupts the JAK2/STAT3 pathway and exhibits an antitumor activity in gastric cancer cells. Cancer Lett. 2013 Jul 10;335(1):145-52.
8	Phase I and biomarker study of OPB-51602, a novel signal transducer and activator of transcription (STAT) 3 inhibitor, in patients with refractory solid malignancies. Ann Oncol. 2015 May;26(5):998-1005.
9	Avontec Announces Results of a Multiple Dose Clinical Phase I Study with Its Drug Candidate AVT-02 UE Ointment After Topical Treatment in Male Healthy Volunteers. Avontec. 2008.