Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DM951PF)

Drug Name

Nonanoic acid biphenyl-2-ylamide Drug Info

Synonyms

CHEMBL270041; nonanoic acid biphenyl-2-ylamide; SCHEMBL15472054

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

Cross-matching ID

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Clinical Trial Drug(s)

Patented Agent(s)

Discontinued Drug(s)

Investigative Drug(s)

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Drug(s) Targeting Acetoacetyl-CoA thiolase (ACAT1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
ATR-01	DMU67HD	Adrenocortical carcinoma	2D11.Z	Phase 1	[2]
PMID25470667-Compound-K-604	DMYZ2UA	N. A.	N. A.	Patented	[3]
Benoxaprofen	DM5ZOX8	Inflammation	1A00-CA43.1	Withdrawn from market	[4]
PMID16242323C18a	DMI5WPQ	Discovery agent	N.A.	Investigative	[5]
PMID16242323C16	DM2Q79X	Discovery agent	N.A.	Investigative	[5]
PMID16242323C22c	DMFDRMH	Discovery agent	N.A.	Investigative	[5]
PMID16242323C26a	DMD0Q7K	Discovery agent	N.A.	Investigative	[5]
Octanoic acid biphenyl-2-ylamide	DM4RGCX	Discovery agent	N.A.	Investigative	[1]
PMID16242323C22d	DMJICNL	Discovery agent	N.A.	Investigative	[5]
PMID16242323C15a	DMM4A7P	Discovery agent	N.A.	Investigative	[5]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

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Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Acetoacetyl-CoA thiolase (ACAT1)	TTK3C21	THIL_HUMAN	Inhibitor	[1]

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References

1	Biphenyl versus phenylpyridazine derivatives: the role of the heterocycle in a series of acyl-CoA:cholesterol acyl transferase inhibitors. J Med Chem. 2008 Mar 13;51(5):1474-7.
2	Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
3	Acyltransferase inhibitors: a patent review (2010-present).Expert Opin Ther Pat. 2015 Feb;25(2):145-58.
4	Inhibition of lyso-PAF: acetyl-CoA acetyltransferase by salicylates and other compounds. Prostaglandins. 1988 Jun;35(6):939-44.
5	Synthesis and biological activity of novel 4-phenyl-1,8-naphthyridin-2(1H)-on-3-yl ureas: potent acyl-CoA:cholesterol acyltransferase inhibitor wit... Bioorg Med Chem Lett. 2006 Jan 1;16(1):44-8.