Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DM9AP55)

Drug Name

LY3473329 Drug Info

Synonyms

Muvalaplin; Muvalaplin [USAN]; HSU2KY4EFK; LY3473329; UNII-HSU2KY4EFK; WHO 12607; 2565656-70-2; LY-3473329; (2S,2'S,2''S)-3,3',3''-((nitrilotris(methylene))tris(benzene-3,1-diyl))tris(2-((R)-pyrrolidin-3-yl)propanoic acid); 3-Pyrrolidineacetic acid, alpha,alpha',alpha''- (nitrilotris(methylene-3,1-phenylenemethylene))tris-,(alphaS,alpha'S,alpha''S,3R,3'R,3''R)-; muvalaplin [INN]; CHEMBL4802585; SCHEMBL22750411; GTPL12939; HY-152857; CS-0641200; (2S)-3-[3-[[bis[[3-[(2S)-2-carboxy-2-[(3R)-pyrrolidin-3-yl]ethyl]phenyl]methyl]amino]methyl]phenyl]-2-[(3R)-pyrrolidin-3-yl]propanoic acid; (2S)-3-[3-[[bis[[3-[(2S)-2-carboxy-2-[(3R)-pyrrolidin-3-yl]ethyl]phenyl]methyl]amino]phenyl]-2-[(3R)-pyrrolidin-3-yl]propanoic acid; 3-Pyrrolidineacetic acid, alpha,alpha',alpha''- [nitrilotris(methylene-3,1-phenylenemethylene)]tris-, (alphaS,alpha'S,alpha''S,3R,3'R,3''R)-

Indication

Disease Entry	ICD 11	Status	REF
Cardiovascular disease	BA00-BE2Z	Phase 2	[1]

Cross-matching ID

PubChem CID: 155369486
TTD Drug ID: DM9AP55

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Clinical Trial Drug(s)

Download the Complete Related Drug List

Drug(s) Targeting Apolipoprotein(a) (LPA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
MG-1102	DMQE4IX	Solid tumour/cancer	2A00-2F9Z	Phase 1	[3]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Apolipoprotein(a) (LPA)	TTGUMYS	APOA_HUMAN	Inhibitor	[2]

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References

1	ClinicalTrials.gov (NCT05563246) KRAKEN: A Phase 2, Randomized, Double-Blind, Placebo-Controlled Study to Investigate the Efficacy and Safety of Oral Once-Daily LY3473329 in Adults With Elevated Lipoprotein(a) at High Risk for Cardiovascular Events. U.S.National Institutes of Health.
2	Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2023. Adis Insight
3	Targeted antivascular therapy with the apolipoprotein(a) kringle V, rhLK8, inhibits the growth and metastasis of human prostate cancer in an orthotopic nude mouse model. Neoplasia. 2012 Apr;14(4):335-43.