Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DM9JV80)

Drug Name

Gp41 HIV-1 vaccine Drug Info

Synonyms

FIV inhibitors, Mymetics; MYM-V101; N-36E; S-291; Anti-retrovirals, Mymetics; Gp41 HIV-1 vaccine (virosomes); Gp41-derived peptides, Mymetics; HIV-1 therapeutics, Mymetics; Gp41 HIV-1 vaccine (virosomes), Mymetics

Indication

Disease Entry	ICD 11	Status	REF
Human immunodeficiency virus infection	1C62	Phase 1	[1]

Cross-matching ID

TTD Drug ID: DM9JV80

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Approved Drug(s)

Clinical Trial Drug(s)

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Drug(s) Targeting Human immunodeficiency virus Glycoprotein 41 (HIV gp41)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Enfuvirtide	DM7YPM1	Human immunodeficiency virus infection	1C62	Approved	[3]
Sifuvirtide	DMMIWCE	Human immunodeficiency virus infection	1C62	Phase 3	[4]
ITV-1	DMCJX79	Human immunodeficiency virus infection	1C62	Phase 2	[5]
T-1249	DMB2NP8	Human immunodeficiency virus infection	1C62	Phase 1/2	[6]
MaC46/M87o	DMIRG15	Human immunodeficiency virus-1 infection	1C62	Phase 1/2	[7]
Multi-envelope HIV vaccine	DMAGCHE	Human immunodeficiency virus infection	1C62	Phase 1	[8]
Combinectin	DMTLP1N	Human immunodeficiency virus infection	1C62	Phase 1	[9]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

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Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Human immunodeficiency virus Glycoprotein 41 (HIV gp41)	TTG90S6	ENV_HV1H2	Modulator	[2]

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References

1	ClinicalTrials.gov (NCT01084343) Investigation of the Safety of an HIV-1 Vaccine Given Intra-muscularly and Intra-nasally to Healthy Female Subjects. U.S. National Institutes of Health.
2	Phase 1 safety and immunogenicity evaluation of ADVAX, a multigenic, DNA-based clade C/B' HIV-1 candidate vaccine. PLoS One. 2010 Jan 25;5(1):e8617.
3	Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services.
4	Broad antiviral activity and crystal structure of HIV-1 fusion inhibitor sifuvirtide.J Biol Chem.2012 Feb 24;287(9):6788-96.
5	Clinical pipeline report, company report or official report of Immunotech Laboratories.
6	HIV entry inhibitors in clinical development. Curr Opin Pharmacol. 2002 Oct;2(5):523-8.
7	DOI: 10.1038/mt.sj.6300124
8	An assessment of the role of chimpanzees in AIDS vaccine research. Altern Lab Anim. 2008 Sep;36(4):381-428.
9	Clinical pipeline report, company report or official report of ViiV Healthcare.