Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DM9P62Y)

Drug Name
GKA1 Drug Info
Synonyms
CHEMBL381434; GKA1; SCHEMBL1794696; RTMFZNZPHCZAFG-UHFFFAOYSA-N; ZINC28523790; BDBM50165037; 6-(3-Isobutoxy-5-isopropoxy-benzoylamino)-nicotinic acid; 6-[(3-isobutoxy-5-isopropoxybenzoyl)amino]-3-pyridinecarboxylic acid; 6-[(3-isobutoxy-5-isopropoxvbenzoyl)amino]-3-pyridinecarboxylic acid
Indication
Disease Entry ICD 11 Status REF
Discovery agent N.A. Investigative [1]
Cross-matching ID
PubChem CID
10044792
TTD Drug ID
DM9P62Y

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
Drug Status:
Clinical Trial Drug(s)
Download the Complete Related Drug List
Drug(s) Targeting Glucokinase (GCK)
Drug Name Drug ID Indication ICD 11 Highest Status REF
LY-2599506 DMMI0RH Diabetic complication 5A2Y Phase 2 [2]
AMG 151 DMGOFL3 Type-2 diabetes 5A11 Phase 2 [2]
PF-04991532 DM94NBE Diabetic complication 5A2Y Phase 2 [3]
GK1-399 DMLFSMX Diabetic complication 5A2Y Phase 2 [4]
LY-2608204 DM4EF9Y Type-2 diabetes 5A11 Phase 2 [5]
PF-04937319 DMQMF4O Type-2 diabetes 5A11 Phase 2 [6]
AZD1656 DMUE90I Diabetic complication 5A2Y Phase 2 [7]
TTP399 DMBKQSZ Type 2 diabetes 5A11 Phase 2 [8]
HMS5552 DMRYM03 Type-2 diabetes 5A11 Phase 1 [9]
BMS-820132 DMCX0H7 Type-2 diabetes 5A11 Phase 1 [10]
⏷ Show the Full List of 10 Drug(s)

Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas
Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Glucokinase (GCK) TTDLNGZ HXK4_HUMAN Activator [1]

References

1 Stimulation of hepatocyte glucose metabolism by novel small molecule glucokinase activators. Diabetes. 2004 Mar;53(3):535-41.
2 This week in therapeutics Endocrine disease. SciBX 2(37); doi:10.1038/scibx.2009.1408. Sept. 24, 2009
3 The hepatoselective glucokinase activator PF-04991532 ameliorates hyperglycemia without causing hepatic steatosis in diabetic rats. PLoS One. 2014 May 23;9(5):e97139.
4 Clinical pipeline report, company report or official report of vTv Therapeutics, NCT02405260.
5 Clinical pipeline report, company report or official report of Eli Lilly.
6 Two dose-ranging studies with PF-04937319, a systemic partial activator of glucokinase, as add-on therapy to metformin in adults with type 2 diabetes. Diabetes Obes Metab. 2015 Aug;17(8):751-9.
7 Clinical pipeline report, company report or official report of AstraZeneca (2009).
8 Clinical pipeline report, company report or official report of vTv Therapeutics.
9 Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
10 Utilization of the Zucker Diabetic Fatty (ZDF) Rat Model for Investigating Hypoglycemia-related Toxicities. Toxicol Pathol. 2015 Aug;43(6):825-37.