Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DM9R51M)

Drug Name

ISIS 116670 Drug Info

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

Cross-matching ID

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Investigative Drug(s)

Download the Complete Related Drug List

Drug(s) Targeting GSK3A messenger RNA (GSK3A mRNA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
aloisine A	DM5U1LN	Discovery agent	N.A.	Investigative	[2]
CHIR-98014	DMVEBT6	Discovery agent	N.A.	Investigative	[3]
indirubin deriv. 8a	DMYLVQF	Discovery agent	N.A.	Investigative	[4]
LEUCETTAMINE B	DMFQEWM	Discovery agent	N.A.	Investigative	[5]
ISIS 116625	DMIJES1	Discovery agent	N.A.	Investigative	[1]
ISIS 116648	DMUOB3S	Discovery agent	N.A.	Investigative	[1]
ISIS 116632	DMW2Q4T	Discovery agent	N.A.	Investigative	[1]
ISIS 116631	DM2X5RT	Discovery agent	N.A.	Investigative	[1]
ISIS 116654	DMBJU2X	Discovery agent	N.A.	Investigative	[1]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

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Drug Therapeutic Target (DTT)

References

1	US patent application no. 6,316,259, Antisense inhibition of glycogen synthase kinase 3 alpha expression.
2	Aloisines, a new family of CDK/GSK-3 inhibitors. SAR study, crystal structure in complex with CDK2, enzyme selectivity, and cellular effects. J Med Chem. 2003 Jan 16;46(2):222-36.
3	Selective glycogen synthase kinase 3 inhibitors potentiate insulin activation of glucose transport and utilization in vitro and in vivo. Diabetes. 2003 Mar;52(3):588-95.
4	Structural basis for the synthesis of indirubins as potent and selective inhibitors of glycogen synthase kinase-3 and cyclin-dependent kinases. J Med Chem. 2004 Feb 12;47(4):935-46.
5	Synthesis and preliminary biological evaluation of new derivatives of the marine alkaloid leucettamine B as kinase inhibitors. Eur J Med Chem. 2010 Feb;45(2):805-10.