General Information of Drug (ID: DM9UZD7)

Drug Name
Bile acid Drug Info
Synonyms Bile Salts; Bile acid; Bile salt; CHEBI:22868
Indication
Disease Entry ICD 11 Status REF
Discovery agent N.A. Investigative [1]
Cross-matching ID
PubChem CID
439520
ChEBI ID
CHEBI:22868
TTD Drug ID
DM9UZD7
INTEDE Drug ID
DR2509

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
DME
Drug Status:
Clinical Trial Drug(s)
Patented Agent(s)
Preclinical Drug(s)
Investigative Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Sodium taurocholate DM3GO0J Type-2 diabetes 5A11 Phase 1/2 [3]
PMID29649907-Compound-INT767 DMA0RI8 N. A. N. A. Patented [4]
PMID29649907-Compound-8 DMV2D5M N. A. N. A. Patented [4]
INT-767 DMRJ9P4 Hepatic fibrosis DB93.0 Preclinical [5]
XL475 DMD8TNK Type-2 diabetes 5A11 Preclinical [6]
INT-777 DMTPB8A Metabolic disorder 5C50-5D2Z Investigative [7]
⏷ Show the Full List of 6 Drug(s)
Drug(s) Metabolized By Cytochrome P450 7A1 (CYP7A1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
ANW-32821 DMMJOZD N. A. N. A. Phase 2 [8]

Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
G-protein coupled bile acid receptor 1 (GPBAR1) TTSDVTR GPBAR_HUMAN Inhibitor [1]

Drug-Metabolizing Enzyme (DME)
DME Name DME ID UniProt ID MOA REF
Cytochrome P450 7A1 (CYP7A1) Main DME DEDZRQ1 CP7A1_HUMAN Substrate [2]

References

1 Synthesis and SAR of 2-aryl-3-aminomethylquinolines as agonists of the bile acid receptor TGR5. Bioorg Med Chem Lett. 2010 Oct 1;20(19):5718-21.
2 FGF15 activates Hippo signaling to suppress bile acid metabolism and liver tumorigenesis. Dev Cell. 2019 Feb 25;48(4):460-474.e9.
3 Bile acids and sphingosine-1-phosphate receptor 2 in hepatic lipid metabolism.Acta Pharmaceutica Sinica B Volume 5, Issue 2, March 2015, Pages 151-157.
4 Farnesoid X receptor modulators 2014-present: a patent review.Expert Opin Ther Pat. 2018 May;28(5):351-364.
5 FXR/TGR5 Dual Agonist Prevents Progression of Nephropathy in Diabetes and Obesity. J Am Soc Nephrol. 2018 Jan;29(1):118-137.
6 Clinical pipeline report, company report or official report of Exelixis (2011).
7 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 37).
8 Cholesterol-metabolizing cytochromes P450. Drug Metab Dispos. 2006 Apr;34(4):513-20.