Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DM9V0KP)

Drug Name

WR85915 Drug Info

Synonyms

azasetron hydrochloride; 123040-16-4; Azasetron HCl; Serotone; Azasetron (hydrochloride); Y-25130 hydrochloride; 141922-90-9; C17H20ClN3O3.HCl; Azasetron hydrochloride [JAN]; 6-chloro-4-methyl-3-oxo-N-(quinuclidin-3-yl)-3,4-dihydro-2H-benzo[b][1,4]oxazine-8-carboxamide hydrochloride; Azasetron hydrochloride (JAN); N-(1-azabicyclo[2.2.2]octan-3-yl)-6-chloro-4-methyl-3-oxo-1,4-benzoxazine-8-carboxamide hydrochloride; 2H-1,4-Benzoxazine-8-carboxamide, 3,4-dihydro-N-1-azabicyclo(2.2.2)oct-3-yl-6-chloro-

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

Cross-matching ID

PubChem CID: 115000
ChEBI ID: CHEMBL31246
CAS Number: CAS 123040-16-4
TTD Drug ID: DM9V0KP

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Approved Drug(s)

Clinical Trial Drug(s)

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Drug(s) Targeting Tubulin (TUB)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Docetaxel	DMDI269	Advanced cancer	2A00-2F9Z	Approved	[2]
Vinorelbine	DMVXFYE	Advanced cancer	2A00-2F9Z	Approved	[3]
Cabazitaxel	DMPAZHC	Breast cancer	2C60-2C65	Approved	[4]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[5]
Ixabepilone	DM2OZ3G	Breast cancer	2C60-2C65	Approved	[4]
Eribulin	DM1DX4Q	Breast cancer	2C60-2C65	Approved	[4]
Epothilon	DMITJRU	Ovarian cancer	2C73	Phase 3	[6]
DOLASTATIN-10	DMDUV1S	Solid tumour/cancer	2A00-2F9Z	Phase 2	[7]
BMS-188797	DML1CK2	Solid tumour/cancer	2A00-2F9Z	Phase 2	[8]
Indibulin	DM6OFJ8	Advanced sarcoma	2A60-2C35	Phase 2	[9]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

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Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Tubulin (TUB)	TTML2WA	NOUNIPROTAC	Inhibitor	[1]

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References

1	Cellular effects of leishmanial tubulin inhibitors on L. donovani. Mol Biochem Parasitol. 2000 Oct;110(2):223-36.
2	Docetaxel: a review of its use in metastatic breast cancer. Drugs. 2005;65(17):2513-31.
3	Vinca alkaloid and MDR1. Gan To Kagaku Ryoho. 2008 Jul;35(7):1086-9.
4	Mullard A: 2010 FDA drug approvals. Nat Rev Drug Discov. 2011 Feb;10(2):82-5.
5	Vitamin K3 disrupts the microtubule networks by binding to tubulin: a novel mechanism of its antiproliferative activity. Biochemistry. 2009 Jul 28;48(29):6963-74.
6	Emerging drugs for ovarian cancer. Expert Opin Emerg Drugs. 2008 Sep;13(3):523-36.
7	Synthesis and biological activity of chimeric structures derived from the cytotoxic natural compounds dolastatin 10 and dolastatin 15. J Med Chem. 1998 Apr 23;41(9):1524-30.
8	Phase I and pharmacokinetic study of BMS-188797, a new taxane analog, administered on a weekly schedule in patients with advanced malignancies. Clin Cancer Res. 2003 Nov 1;9(14):5187-94.
9	2011 Pipeline of ZioPharm.