Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DM9VLS2)

Drug Name

Fumarate Drug Info

Synonyms

Fumarate(2-); (2E)-but-2-enedioate; 142-42-7; (E)-2-Butenedioate; (E)-Butenedioic acid; but-2-enedioate; Fumarate dianion; (E)-but-2-enedioate; butenedioate; Fumerate; 2-Butenedioic acid (E)-, ion(2-); AC1NUT2F; Fumaric acid, ion(2-); AC1Q22C1; DTXSID9037660; CHEBI:36180; CHEBI:29806; VZCYOOQTPOCHFL-OWOJBTEDSA-L; trans-1,2-Ethenedicarboxylic acid; (E)-1,2-Ethylenedicarboxylic acid; (E)-2-butenedioic acid, ion(2-); trans-1,2-Ethylenediccarboxylic acid; CJ-10837; 3861-EP2371811A2; 3861-EP2316829A1; 3861-EP2316450A1

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

Cross-matching ID

PubChem CID: 5460307
ChEBI ID: CHEBI:29806
CAS Number: CAS 142-42-7
TTD Drug ID: DM9VLS2
VARIDT Drug ID: DR00498
INTEDE Drug ID: DR2652

Molecule-Related Drug Atlas

Molecule Type:

DTT

DME

Drug Status:

Approved Drug(s)

Investigative Drug(s)

Download the Complete Related Drug List

Drug(s) Targeting Bacterial Fumarate reductase flavoprotein (Bact frdA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Thiabendazole	DM7YCK3	Ascariasis	1F62	Approved	[3]
Oxantel pamoate	DMZ30JT	Trichuris trichiura infection	1F6G	Approved	[3]
Morantel tartrate	DM560Y3	Mature gastrointestinal nematode infection	1F6Y	Approved	[3]
Flavin-Adenine Dinucleotide	DM5S4GK	Discovery agent	N.A.	Investigative	[1]
Heme	DMGC287	Discovery agent	N.A.	Investigative	[4]
2,3-DIMETHYL-1,4-NAPHTHOQUINONE	DMGXVBA	Discovery agent	N.A.	Investigative	[4]
Citraconic acid	DMCIM9A	Discovery agent	N.A.	Investigative	[5]
2-[1-(4-CHLORO-PHENYL)-ETHYL]-4,6-DINITRO-PHENOL	DMUZDSC	Discovery agent	N.A.	Investigative	[4]
2-HEPTYL-4-HYDROXY QUINOLINE N-OXIDE	DMJ3ATL	Discovery agent	N.A.	Investigative	[4]
Malate Like Intermediate	DM4OQWZ	Discovery agent	N.A.	Investigative	[5]
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⏷ Show the Full List of 10 Drug(s)

Drug(s) Metabolized By Fumarate reductase flavoprotein (frdA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[2]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Bacterial Fumarate reductase flavoprotein (Bact frdA)	TTHDSE2	FRDA_HELPY	Inhibitor	[1]

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Drug-Metabolizing Enzyme (DME)

DME Name	DME ID	UniProt ID	MOA	REF
Fumarate reductase flavoprotein (frdA)^{Main DME}	DEQUXZ5	FRDA_WOLSU	Substrate	[2]

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References

1	How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6.
2	Wolinella succinogenes quinol:fumarate reductase and its comparison to E. coli succinate:quinone reductase. FEBS Lett. 2003 Nov 27;555(1):21-8.
3	Fumarate reductase is essential for Helicobacter pylori colonization of the mouse stomach. Microb Pathog. 2000 Nov;29(5):279-87.
4	The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42.
5	DrugBank 3.0: a comprehensive resource for 'omics' research on drugs. Nucleic Acids Res. 2011 Jan;39(Database issue):D1035-41.