Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DM9YSSY)

• Drug Name: VM1500A Drug Info
• Synonyms: 867365-76-2; RO-0335; RO0335; Depulfavirine; Ro 0335; VM-1500A; 2-(4-bromo-3-(3-chloro-5-cyanophenoxy)-2-fluorophenyl)-N-(2-chloro-4-sulfamoylphenyl)acetamide; 2-[4-bromo-3-(3-chloro-5-cyanophenoxy)-2-fluorophenyl]-N-(2-chloro-4-sulfamoylphenyl)acetamide; ZP6H7RDZ5Q; RO-4970335; VM1500A; N-[4-(aminosulfonyl)-2-chlorophenyl]-4-bromo-3-(3-chloro-5-cyanophenoxy)-2-fluoroBenzeneacetamide; RO4970335; Benzeneacetamide, N-(4-(aminosulfonyl)-2-chlorophenyl)-4-bromo-3-(3-chloro-5-cyanophenoxy)-2-fluoro-; Benzeneacetamide, N-[4-(aminosulfonyl)-2-chlorophenyl]-4-bromo-3-(3-chloro-5-cyanophenoxy)-2-fluoro-; Depulfavirine [INN]; UNII-ZP6H7RDZ5Q; SCHEMBL2638090; CHEMBL4438269; EX-A892; Ro-0335 pound>>Ro0335; BCP28161; AKOS027338665; 2-[4-bromo-3-(3-chloro-5-cyano-phenoxy)-2-fluoro-phenyl]-N-(2-chloro-4-sulfamoyl-phenyl)acetamide; HY-13053; MS-30329; CS-0003172; FT-0700384; A922653; J-690367; Methyl (2-{(R)-(3-chlorophenyl)[(3R)-1-({(2S)-2-(methylamino)-3-[(3R)-tetrahydro-2H-pyran-3-yl]propyl}carbamoyl)-3-piperidinyl]metho xy}ethyl)carbamate; VM5

Indication

Disease Entry	ICD 11	Status	REF
Human immunodeficiency virus-1 infection	1C62	Phase 2/3	[1]

• Cross-matching ID:
  PubChem CID: 11599486
  TTD Drug ID: DM9YSSY

Molecule-Related Drug Atlas

Drug(s) Targeting Telomerase reverse transcriptase (TERT)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Berberine	DMC5Q8X	N. A.	N. A.	Phase 4	[3]
GV1001	DMHULRK	Pancreatic cancer	2C10	Phase 3	[4]
Imetelstat	DMONWJ4	Myelodysplastic syndrome	2A37	Phase 2/3	[5]
Dendritic cell vaccine	DML4PMG	Ovarian cancer	2C73	Phase 2	[6]
GRNVAC1	DMAHOEP	Acute myeloid leukaemia	2A60	Phase 2	[7]
Vx-001	DMDKWA3	Breast cancer	2C60-2C65	Phase 2	[8]
CB-10-01	DM2IFYZ	Melanoma	2C30	Phase 2	[9]
Epithalon	DMWSGZU	Ocular inflammation	9C61.24	Phase 1/2	[10]
OBP-301	DM9MF08	Breast cancer	2C60-2C65	Phase 1/2	[11]
KML-001	DM1D2O0	Solid tumour/cancer	2A00-2F9Z	Phase 1	[12]

Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Telomerase reverse transcriptase (TERT)	TTUJFD0	TERT_HUMAN	Inhibitor	[2]

References

• [1] ClinicalTrials.gov (NCT05204394) Multicenter, Open-label, Randomized, Active Control Study to Evaluate Efficacy and Safety of Switching to VM-1500A-LAI + 2NRTIs From the 1st Line Standard of Care Therapy. U.S.National Institutes of Health.
• [2] Biochemical profiling of anti-HIV prodrug Elsulfavirine (Elpida(?)) and its active form VM1500A against a panel of twelve human carbonic anhydrase isoforms. J Enzyme Inhib Med Chem. 2021 Dec;36(1):1056-1060.
• [3] Stage specificity of Plasmodium falciparum telomerase and its inhibition by berberine. Parasitol Int. 2002 Mar;51(1):99-103.
• [4] Telomerase peptide vaccination of patients with non-resectable pancreatic cancer: A dose escalating phase I/II study. Br J Cancer. 2006 Dec 4;95(11):1474-82.
• [5] Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
• [6] In vitro activation of cytotoxic T-lymphocytes by hTERT-pulsed dendritic cells. J Immunotoxicol. 2009 Dec;6(4):243-8.
• [7] Targeting telomerase-expressing cancer cells. J Cell Mol Med. 2011 Jul;15(7):1433-42.
• [8] Clinical pipeline report, company report or official report of Vaxon-biotech.
• [9] Telomerase immunity from bench to bedside: round one. J Transl Med. 2007 Feb 26;5:12.
• [10] Epithalon peptide induces telomerase activity and telomere elongation in human somatic cells. Bull Exp Biol Med. 2003 Jun;135(6):590-2.
• [11] Telomerase-specific replication-selective virotherapy for human cancer. Clin Cancer Res. 2004 Jan 1;10(1 Pt 1):285-92.
• [12] National Cancer Institute Drug Dictionary (drug id 672554).