General Information of Drug (ID: DMA9FKY)

Drug Name
AG140699 Drug Info
Indication
Disease Entry ICD 11 Status REF
Melanoma 2C30 Phase 2 [1]
Therapeutic Class
Anticancer Agents
Cross-matching ID
TTD Drug ID
DMA9FKY

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
Drug Status:
Approved Drug(s)
Clinical Trial Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Nicotinamide DMUPE07 Acne vulgaris ED80 Approved [3]
KU-0058948 DMSA4HZ Ovarian cancer 2C73 Approved [4]
Niraparib Tosylate DMLPSWQ Fallopian tube cancer 2C74 Approved [5]
CC-486 DMTNQB0 Acute myeloid leukaemia 2A60 Phase 3 [6]
Nicaraven DMFBNA3 Cerebrovascular disease 8B2Z Phase 3 [7]
PMID27841036-Compound-37 DM0OVZ2 Ovarian cancer 2C73 Phase 2 [8]
Stenoparib DMKVBL8 Ovarian cancer 2C73 Phase 2 [9]
AZD5305 DMW9R1C Prostate cancer 2C82.0 Phase 2 [10]
AMXI 5001 DMR9H6B Solid tumour/cancer 2A00-2F9Z Phase 1/2 [11]
NMS-03305293 DM2XIRW Solid tumour/cancer 2A00-2F9Z Phase 1 [12]
⏷ Show the Full List of 10 Drug(s)

Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Poly [ADP-ribose] polymerase 1 (PARP1) TTVDSZ0 PARP1_HUMAN Inhibitor [2]

References

1 Critical Care Nephrology, Claudio Ronco,Rinaldo Bellomo,John A. Kellum. Page(444).
2 Poly(ADP-ribose) polymerase and the therapeutic effects of its inhibitors. Nat Rev Drug Discov. 2005 May;4(5):421-40.
3 beta-1,2,3-Triazolyl-nucleosides as nicotinamide riboside mimics. Nucleosides Nucleotides Nucleic Acids. 2009 Mar;28(3):238-59.
4 Structural basis for inhibitor specificity in human poly(ADP-ribose) polymerase-3. J Med Chem. 2009 May 14;52(9):3108-11.
5 Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services.
6 Tricyclic benzimidazoles as potent poly(ADP-ribose) polymerase-1 inhibitors. J Med Chem. 2003 Jan 16;46(2):210-3.
7 Inhibition of poly (ADP-ribose) polymerase as a protective effect of nicaraven in ionizing radiation- and ara-C-induced cell death. Anticancer Res. 2006 Sep-Oct;26(5A):3421-7.
8 PARP inhibitors as antitumor agents: a patent update (2013-2015).Expert Opin Ther Pat. 2017 Mar;27(3):363-382.
9 Clinical pipeline report, company report or official report of Allarity Therapeutics.
10 Preclinical Characterization of AZD5305, A Next-Generation, Highly Selective PARP1 Inhibitor and Trapper. Clin Cancer Res. 2022 Nov 1;28(21):4724-4736.
11 AMXI-5001, a novel dual parp1/2 and microtubule polymerization inhibitor for the treatment of human cancers. Am J Cancer Res. 2020 Aug 1;10(8):2649-2676.
12 NMS-P293, a PARP-1 selective inhibitor with no trapping activity and high CNS penetration, possesses potent in vivo efficacy and represents a novel therapeutic option for brain localized metastases and glioblastoma. Cancer Res 2018;78(13 Suppl):Abstract nr 4843.