Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMA9REV)

Drug Name

Elosulfase alfa Drug Info

Synonyms

Vimizim

Indication

Disease Entry	ICD 11	Status	REF
Mucopolysaccharidosis	5C56.3	Approved	[1]

Cross-matching ID

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Clinical Trial Drug(s)

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Drug(s) Targeting N-acetylgalactosamine 6 sulfatase (GALNS)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
BMN-110	DMBXR23	Morquio syndrome	5C56.32	Phase 3	[3]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

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Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
N-acetylgalactosamine 6 sulfatase (GALNS)	TTT9YPO	GALNS_HUMAN	Modulator	[2]

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References

1	URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 7392).
2	2014 FDA drug approvals. Nat Rev Drug Discov. 2015 Feb;14(2):77-81.
3	Efficacy and safety of enzyme replacement therapy with BMN 110 (elosulfase alfa) for Morquio A syndrome (mucopolysaccharidosis IVA): a phase 3 randomised placebo-controlled study. J Inherit Metab Dis. 2014 Nov;37(6):979-90.