Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMAGE91)

• Drug Name: RG7800 Drug Info

Indication

Disease Entry	ICD 11	Status	REF
Spinal muscular atrophy	8B61	Phase 1/2	[1]

• Cross-matching ID:
  PubChem CID: 89741565
  TTD Drug ID: DMAGE91

Molecule-Related Drug Atlas

Drug(s) Targeting Survival motor neuron protein (SMN1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Zolgensma	DM57O90	Spinal muscular atrophy	8B61	Approved	[4]
LMI070	DM4OAIU	Spinal muscular atrophy	8B61	Phase 3	[5]

Drug(s) Affected By Survival motor neuron protein (SMN2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Amikacin	DM5PDRB	Bacteremia	1A73	Approved	[6]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[6]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[7]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[8]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[9]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[10]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[11]
Tobramycin	DMUI0CH	Bacteremia	1A73	Approved	[6]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[12]
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[13]

Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Survival motor neuron protein (SMN1)	TT8QL6X	SMN_HUMAN	Modulator	[2]

Drug Off-Target (DOT)

DOT Name	DOT ID	UniProt ID	Interaction	REF
Survival motor neuron protein (SMN2)	OT54RLO1	SMN_HUMAN	Gene/Protein Processing	[3]

References

• [1] Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800039744)
• [2] Assays for the Identification and Prioritization of Drug Candidates for Spinal Muscular Atrophy. Assay Drug Dev Technol. 2014 August 1; 12(6): 315-341.
• [3] The oral splicing modifier RG7800 increases full length survival of motor neuron 2 mRNA and survival of motor neuron protein: Results from trials in healthy adults and patients with spinal muscular atrophy. Neuromuscul Disord. 2019 Jan;29(1):21-29. doi: 10.1016/j.nmd.2018.10.001. Epub 2018 Oct 30.
• [4] Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health Human Services.
• [5] Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
• [6] Translational readthrough by the aminoglycoside geneticin (G418) modulates SMN stability in vitro and improves motor function in SMA mice in vivo. Hum Mol Genet. 2009 Apr 1;18(7):1310-22. doi: 10.1093/hmg/ddp030. Epub 2009 Jan 15.
• [7] Quantitative proteomics reveals a broad-spectrum antiviral property of ivermectin, benefiting for COVID-19 treatment. J Cell Physiol. 2021 Apr;236(4):2959-2975. doi: 10.1002/jcp.30055. Epub 2020 Sep 22.
• [8] Mitochondrial Uncoupling Induces Epigenome Remodeling and Promotes Differentiation in Neuroblastoma. Cancer Res. 2023 Jan 18;83(2):181-194. doi: 10.1158/0008-5472.CAN-22-1029.
• [9] Physiological and toxicological transcriptome changes in HepG2 cells exposed to copper. Physiol Genomics. 2009 Aug 7;38(3):386-401.
• [10] Low doses of cisplatin induce gene alterations, cell cycle arrest, and apoptosis in human promyelocytic leukemia cells. Biomark Insights. 2016 Aug 24;11:113-21.
• [11] Prenatal arsenic exposure and the epigenome: identifying sites of 5-methylcytosine alterations that predict functional changes in gene expression in newborn cord blood and subsequent birth outcomes. Toxicol Sci. 2015 Jan;143(1):97-106. doi: 10.1093/toxsci/kfu210. Epub 2014 Oct 10.
• [12] Blood transcript immune signatures distinguish a subset of people with elevated serum ALT from others given acetaminophen. Clin Pharmacol Ther. 2016 Apr;99(4):432-41.
• [13] 5-Fluorouracil up-regulates interferon pathway gene expression in esophageal cancer cells. Anticancer Res. 2005 Sep-Oct;25(5):3271-8.