Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMAH12E)

Drug Name

F-15845 Drug Info

Synonyms

UNII-3VKL9K971D; 3VKL9K971D; F-15845; (-)-F-15845; 2H-1,5-Benzoxathiepin-3-amine, 3,4-dihydro-N-((2S)-3-((2-methoxyphenyl)thio)-2-methylpropyl)-, hydrobromide, (3R)-; 3-(R)-(3-(2-Methoxyphenylthio-2-(S)-methylpropyl)amino)-3,4-dihydro-2H-1,5-benzoxathiepine bromhydrate; (-)-(3R)-N-((2S)-3-((2-Methoxyphenyl)sulfanyl)-2-methylpropyl)-3,4-dihydro-2H-1,5-benzoxathiepin-3-amine hydrobromide

Indication

Disease Entry	ICD 11	Status	REF
Angina pectoris	BA40	Phase 1	[1]

Cross-matching ID

PubChem CID: 72941926
CAS Number: CAS 866760-23-8
TTD Drug ID: DMAH12E

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Approved Drug(s)

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Drug(s) Targeting Voltage-gated sodium channel alpha Nav1.5 (SCN5A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Mephenytoin	DM5UGDK	Epilepsy	8A60-8A68	Approved	[3]
Mexiletine	DMCTE9R	Ventricular tachycardia	BC71	Approved	[4]
Fosphenytoin	DMOX3LB	Epilepsy	8A60-8A68	Approved	[3]
Disopyramide	DM5SYZP	Long QT syndrome	BC65.0	Approved	[4]
LOMERIZINE	DME0TC8	Migraine	8A80	Approved	[5]
Tetrodotoxin	DMWMPRG	Bacterial infection	1A00-1C4Z	Approved	[6]
Dyclonine	DMU6OFP	Pain	MG30-MG3Z	Approved	[7]
Moricizine	DMOMBJW	Arrhythmia	BC9Z	Approved	[8]
Ethotoin	DMXWOCP	Complex partial seizure	8A68.0	Approved	[9]
Prilocaine	DMI7DZ2	Pain	MG30-MG3Z	Approved	[7]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

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Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Voltage-gated sodium channel alpha Nav1.5 (SCN5A)	TTZOVE0	SCN5A_HUMAN	Inhibitor	[2]

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References

1	Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800023448)
2	Selective inhibition of persistent sodium current by F 15845 prevents ischaemia-induced arrhythmias. Br J Pharmacol. 2010 Sep;161(1):79-91.
3	Lacosamide: a new approach to target voltage-gated sodium currents in epileptic disorders. CNS Drugs. 2009;23(7):555-68.
4	Effect of sodium channel blockers on ST segment, QRS duration, and corrected QT interval in patients with Brugada syndrome. J Cardiovasc Electrophysiol. 2000 Dec;11(12):1320-9.
5	Medicinal chemistry of neuronal voltage-gated sodium channel blockers. J Med Chem. 2001 Jan 18;44(2):115-37.
6	Halothane attenuates the cerebroprotective action of several Na+ and Ca2+ channel blockers via reversal of their ion channel blockade. Eur J Pharmacol. 2002 Oct 4;452(2):175-81.
7	Monoamine transporter and sodium channel mechanisms in the rapid pressor response to cocaine. Pharmacol Biochem Behav. 1998 Feb;59(2):305-12.
8	From first class to third class: recent upheaval in antiarrhythmic therapy--lessons from clinical trials. Am J Cardiol. 1996 Aug 29;78(4A):28-33.
9	How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6.