Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMAK789)

Drug Name

4-(2,4-dichloro-phenoxy)-4'-fluoro-biphenyl-3-ol Drug Info

Synonyms

2-(2,4-dichlorophenoxy)-5-(4-fluorophenyl)phenol; Triclosan derivative, 19; CHEMBL260979

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

Cross-matching ID

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Approved Drug(s)

Clinical Trial Drug(s)

Investigative Drug(s)

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Drug(s) Targeting Plasmodium Enoyl-ACP reductase (Malaria fabI)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[2]
Epigallocatechin gallate	DMCGWBJ	Hepatic fibrosis	DB93.0	Phase 3	[3]
Nicotinamide-Adenine-Dinucleotide	DM9LRKB	N. A.	N. A.	Investigative	[4]
Beta-D-Glucose	DM5IHYP	Discovery agent	N.A.	Investigative	[4]
MORIN	DM2OGZ5	Discovery agent	N.A.	Investigative	[5]
3,7,3',4'-TETRAHYDROXYFLAVONE	DMES906	Discovery agent	N.A.	Investigative	[5]
(-)-CATECHINGALLATE	DMZOGSK	Discovery agent	N.A.	Investigative	[5]
Thiolactomycin	DMBAWDG	Malaria	1F40-1F45	Investigative	[2]
GALLOCATECHIN GALLATE	DMX2084	Discovery agent	N.A.	Investigative	[5]
Diazaborines	DM5UFZX	Discovery agent	N.A.	Investigative	[6]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

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Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Plasmodium Enoyl-ACP reductase (Malaria fabI)	TTNX2CS	Q965D5_PLAFA	Inhibitor	[1]

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References

1	X-ray structural analysis of Plasmodium falciparum enoyl acyl carrier protein reductase as a pathway toward the optimization of triclosan antimalar... J Biol Chem. 2007 Aug 31;282(35):25436-44.
2	Novel molecular targets for antimalarial drug development. Chem Biol Drug Des. 2008 Apr;71(4):287-97.
3	Green tea catechins potentiate triclosan binding to enoyl-ACP reductase from Plasmodium falciparum (PfENR). J Med Chem. 2007 Feb 22;50(4):765-75.
4	How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6.
5	Inhibition of Plasmodium falciparum fatty acid biosynthesis: evaluation of FabG, FabZ, and FabI as drug targets for flavonoids. J Med Chem. 2006 Jun 1;49(11):3345-53.
6	Lipid biosynthesis as a target for antibacterial agents. Prog Lipid Res. 2001 Nov;40(6):467-97.