Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMANC59)

• Drug Name: AZD-3241 Drug Info
• Synonyms: Parkinson's disease therapeutic, AstraZeneca

Indication

Disease Entry	ICD 11	Status	REF
Parkinson disease	8A00.0	Phase 2	[1]

• Cross-matching ID:
  PubChem CID: 11528958
  CAS Number: CAS 890655-80-8
  TTD Drug ID: DMANC59

Molecule-Related Drug Atlas

Drug(s) Targeting Myeloperoxidase (MPO)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
E-101	DMM1YC4	Infectious disease	1A00-CA43.1	Phase 3	[3]
Mitiperstat	DM0BL2G	Heart failure with preserved ejection fraction	BD11.0	Phase 2/3	[4]
AZD4831	DMRP3N8	Heart failure	BD10-BD13	Phase 1	[5]
AZD5904	DM8SCON	Chronic obstructive pulmonary disease	CA22	Discontinued in Phase 1	[6]
INV-311	DM8BZVI	Inflammation	1A00-CA43.1	Investigative	[7]
4-aminobenzoic acid hydrazide	DMP2GN7	Discovery agent	N.A.	Investigative	[8]

Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Myeloperoxidase (MPO)	TTVCZPI	PERM_HUMAN	Inhibitor	[2]

References

• [1] ClinicalTrials.gov (NCT02388295) AZD3241 PET MSA Trial, Phase 2, Randomized,12 Week Safety and Tolerability Trial With PET in MSA Patients. U.S. National Institutes of Health.
• [2] Effect of the myeloperoxidase inhibitor AZD3241 on microglia: a PET study in Parkinson's disease. Brain. 2015 Sep;138(Pt 9):2687-700.
• [3] In vitro antibacterial activity of E-101 Solution, a novel myeloperoxidase-mediated antimicrobial, against Gram-positive and Gram-negative pathogens. J Antimicrob Chemother. 2011 Feb;66(2):335-42.
• [4] Discovery of AZD4831, a Mechanism-Based Irreversible Inhibitor of Myeloperoxidase, As a Potential Treatment for Heart Failure with Preserved Ejection Fraction. J Med Chem. 2022 Sep 8;65(17):11485-11496.
• [5] Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
• [6] Clinical pipeline report, company report or official report of AstraZeneca (2009).
• [7] URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 2789).
• [8] Myeloperoxidase expression as a potential determinant of parthenolide-induced apoptosis in leukemia bulk and leukemia stem cells. J Pharmacol Exp Ther. 2010 Nov;335(2):389-400.