Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMAXHLK)

• Drug Name: NQN-1 Drug Info
• Synonyms: PPM-18; NSC 73233

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

• Cross-matching ID:
  PubChem CID: 4882
  CAS Number: CAS 65240-86-0
  TTD Drug ID: DMAXHLK

Molecule-Related Drug Atlas

Drug(s) Targeting Histone deacetylase 6 (HDAC6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Citarinostat	DMQLODU	Multiple myeloma	2A83	Phase 1	[3]
KA2507	DMW0H9Y	Solid tumour/cancer	2A00-2F9Z	Phase 1	[3]
PMID29671355-Compound-62	DMWRS34	N. A.	N. A.	Patented	[4]
PMID29671355-Compound-43	DMVPMWJ	N. A.	N. A.	Patented	[4]
PMID29671355-Compound-25	DMPV0KZ	N. A.	N. A.	Patented	[4]
PMID29671355-Compound-21	DMPJN0M	N. A.	N. A.	Patented	[4]
PMID29671355-Compound-31	DM3H78D	N. A.	N. A.	Patented	[4]
PMID29671355-Compound-56	DM0VBMI	N. A.	N. A.	Patented	[4]
PMID29671355-Compound-67	DM1RPL4	N. A.	N. A.	Patented	[4]
PMID29671355-Compound-23	DMUBOEX	N. A.	N. A.	Patented	[4]

Drug(s) Affected By Urokinase-type plasminogen activator (PLAU)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[5]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[6]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[7]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[8]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[9]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[5]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[10]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[2]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[11]
Atorvastatin	DMF28YC	Acute coronary syndrome	BA41	Approved	[12]

Drug(s) Affected By 72 kDa type IV collagenase (MMP2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[13]
Selenium	DM25CGV	N. A.	N. A.	Approved	[14]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[15]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[16]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[17]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[18]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[19]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[2]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[20]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[21]

Drug(s) Affected By Matrix metalloproteinase-9 (MMP9)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[22]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[23]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[24]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[25]
Selenium	DM25CGV	N. A.	N. A.	Approved	[14]
Pentosan Polysulfate	DM2HRKE	Interstitial cystitis	GC00.3	Approved	[26]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[27]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[28]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[29]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[30]

Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Histone deacetylase 6 (HDAC6)	TT5ZKDI	HDAC6_HUMAN	Inhibitor	[1]

Drug Off-Target (DOT)

DOT Name	DOT ID	UniProt ID	Interaction	REF
72 kDa type IV collagenase (MMP2)	OT5NIWA2	MMP2_HUMAN	Protein Interaction/Cellular Processes	[2]
Matrix metalloproteinase-9 (MMP9)	OTB2QDAV	MMP9_HUMAN	Protein Interaction/Cellular Processes	[2]
Urokinase-type plasminogen activator (PLAU)	OTX0QGKK	UROK_HUMAN	Protein Interaction/Cellular Processes	[2]

References

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• [20] Aspirin inhibits MMP-2 and MMP-9 expressions and activities through upregulation of PPARalpha/gamma and TIMP gene expressions in ox-LDL-stimulated macrophages derived from human monocytes. Pharmacology. 2009;83(1):18-25. doi: 10.1159/000166183. Epub 2008 Oct 30.
• [21] Repetitive nonlethal oxidant injury to retinal pigment epithelium decreased extracellular matrix turnover in vitro and induced sub-RPE deposits in vivo. Invest Ophthalmol Vis Sci. 2006 Sep;47(9):4098-112. doi: 10.1167/iovs.05-1230.
• [22] Cannabidiol Effectively Promoted Cell Death in Bladder Cancer and the Improved Intravesical Adhesion Drugs Delivery Strategy Could Be Better Used for Treatment. Pharmaceutics. 2021 Sep 7;13(9):1415. doi: 10.3390/pharmaceutics13091415.
• [23] Arsenite and cadmium promote the development of mammary tumors. Carcinogenesis. 2020 Jul 14;41(7):1005-1014. doi: 10.1093/carcin/bgz176.
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