Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMB06TA)

Drug Name

N-butylgalactonojirimycin Drug Info

Synonyms

N-butylgalactonojirimycin; CHEMBL485842

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

Cross-matching ID

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Approved Drug(s)

Clinical Trial Drug(s)

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Drug(s) Targeting Ceramide glucosyltransferase (UGCG)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Eliglustat tartrate	DMSRZAO	Metabolic disorder	5C50-5D2Z	Approved	[2]
Miglustat	DM5J64S	Niemann-Pick disease type C		Approved	[3]
Venglustat	DMLPEZS	Fabry disease	5C56.01	Phase 2	[4]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

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Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Ceramide glucosyltransferase (UGCG)	TTPHEX3	CEGT_HUMAN	Inhibitor	[1]

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References

1	Accumulation of glucosylceramide in murine testis, caused by inhibition of beta-glucosidase 2: implications for spermatogenesis. J Biol Chem. 2007 Nov 9;282(45):32655-64.
2	2014 FDA drug approvals. Nat Rev Drug Discov. 2015 Feb;14(2):77-81.
3	Effect of miglustat on bone disease in adults with type 1 Gaucher disease: a pooled analysis of three multinational, open-label studies. Clin Ther. 2007 Aug;29(8):1645-54.
4	Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)