Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMB26IK)

Drug Name

PACAP-27 Drug Info

Synonyms

pituitary adenylate cyclase activating polypeptide-27

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

Cross-matching ID

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Clinical Trial Drug(s)

Investigative Drug(s)

Download the Complete Related Drug List

Drug(s) Targeting Helodermin-preferring VIP receptor (VIPR2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
PB1046	DM8MJ3F	Heart failure	BD10-BD13	Phase 2	[3]
RG-7103	DM2IDQ9	Chronic obstructive pulmonary disease	CA22	Phase 1	[4]
helodermin	DMIUABO	Discovery agent	N.A.	Investigative	[5]
PB-1120	DMX7WU9	Discovery agent	N.A.	Investigative	[6]
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Drug(s) Targeting Vasoactive intestinal polypeptide receptor 1 (VIPR1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Vasoactive intestinal peptide	DMRJ5LP	Chronic obstructive pulmonary disease	CA22	Phase 2	[7]
helodermin	DMIUABO	Discovery agent	N.A.	Investigative	[8]
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Drug(s) Targeting PACAP type I receptor (PAC1R)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
AMG 301	DMO72IF	Migraine	8A80	Phase 2	[9]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Helodermin-preferring VIP receptor (VIPR2)	TT4O5P0	VIPR2_HUMAN	Agonist	[2]
PACAP type I receptor (PAC1R)	TT5OREU	PACR_HUMAN	Agonist	[2]
Vasoactive intestinal polypeptide receptor 1 (VIPR1)	TTCL30I	VIPR1_HUMAN	Agonist	[2]

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References

1	URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 2257).
2	A systematic comparison of intracellular cyclic AMP and calcium signalling highlights complexities in human VPAC/PAC receptor pharmacology. Neuropharmacology. 2006 Nov;51(6):1086-98.
3	Clinical pipeline report, company report or official report of PhaseBio Pharmaceuticals.
4	Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800027925)
5	Analogues of VIP, helodermin, and PACAP discriminate between rat and human VIP1 and VIP2 receptors. Ann N Y Acad Sci. 1998 Dec 11;865:247-52.
6	Company report (PhaseBio)
7	Emerging treatments for pulmonary arterial hypertension. Expert Opin Emerg Drugs. 2006 Nov;11(4):609-19.
8	Stable expression of the recombinant human VIP1 receptor in clonal Chinese hamster ovary cells: pharmacological, functional and molecular properties. Eur J Pharmacol. 1996 Apr 29;302(1-3):207-14.
9	Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)