Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMB83V4)

• Drug Name: IBI318 Drug Info

Indication

Disease Entry	ICD 11	Status	REF
Non-small-cell lung cancer	2C25	Phase 1	[1]

• Cross-matching ID: TTD Drug ID: DMB83V4

Molecule-Related Drug Atlas

Drug(s) Targeting Programmed cell death protein 1 (PD-1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Nivolumab	DMAB9QE	Melanoma	2C30	Approved	[3]
Tislelizumab	DMGVUO5	Hodgkin lymphoma	2B30	Approved	[4]
MK-3475	DMBYNW0	Melanoma	2C30	Approved	[3]
Pembrolizumab	DMFQEA6	Melanoma	2C30	Approved	[5]
Cemiplimab	DMKMJHE	Cutaneous squamous cell carcinoma	2C30	Approved	[6]
Retifanlimab	DMRKTCP	Neuroendocrine cancer	2B72.1	Approved	[7]
Sintilimab	DMGWR0C	Hodgkin lymphoma	2B30	Approved	[8]
Dostarlimab	DM78NWP	Endometrial cancer	2C76	Approved	[9]
Toripalimab	DMSGA6Z	Demodex blepharitis	1G07	Approved in China	[10]
PDR001	DM53J6B	Melanoma	2C30	Phase 3	[11]

Drug(s) Targeting Programmed cell death 1 ligand 1 (PD-L1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Avelumab	DMSZLJR	Merkel cell carcinoma	2C34	Approved	[12]
Durvalumab	DM4PVDY	Urothelial carcinoma	2C92.0	Approved	[13]
RG-7446	DM69XMQ	Urothelial carcinoma	2C92.0	Approved	[14]
Bavencio	DMU9C8F	Merkel cell carcinoma	2C34	Approved	[15]
Atezolizumab	DMMF8U0	Non-small-cell lung cancer	2C25	Approved	[16]
Sugemalimab	DMH5YQ3	Non-small-cell lung cancer	2C25	Approved in China	[17]
KN046	DMSDBPG	Non-small-cell lung cancer	2C25.Y	Phase 3	[18]
MEDI4736	DM5X849	Solid tumour/cancer	2A00-2F9Z	Phase 3	[19]
MPDL-3280A	DM9K3LM	Melanoma	2C30	Phase 3	[20]
CS1001	DMSY0NE	Non-small-cell lung cancer	2C25	Phase 3	[21]

Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Programmed cell death 1 ligand 1 (PD-L1)	TT8ZLTI	PD1L1_HUMAN	Inhibitor	[2]
Programmed cell death protein 1 (PD-1)	TTNBFWK	PDCD1_HUMAN	Inhibitor	[2]

References

• [1] ClinicalTrials.gov (NCT04777084) The Efficacy and Safety of the Bispecific Anti-PD-1/PD-L1 Antibody IBI318 Combined With Lenvatinib in NSCLC.. U.S. National Institutes of Health.
• [2] Clinical pipeline report, company report or official report of Innovent.
• [3] 2014 FDA drug approvals. Nat Rev Drug Discov. 2015 Feb;14(2):77-81.
• [4] Tislelizumab: an investigational anti-PD-1 antibody for the treatment of advanced non-small cell lung cancer (NSCLC). Expert Opin Investig Drugs. 2020 Dec;29(12):1355-1364.
• [5] Development of Inhibitors of the Programmed Cell Death-1/Programmed Cell Death-Ligand 1 Signaling Pathway.J Med Chem. 2019 Feb 28;62(4):1715-1730.
• [6] 2018 FDA drug approvals.Nat Rev Drug Discov. 2019 Feb;18(2):85-89.
• [7] Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
• [8] Sintilimab: First Global Approval. Drugs. 2019 Feb;79(3):341-346.
• [9] Dostarlimab in the treatment of recurrent or primary advanced endometrial cancer. Future Oncol. 2021 Mar;17(8):877-892.
• [10] Toripalimab: the First Domestic Anti-Tumor PD-1 Antibody in China. Front Immunol. 2022 Jan 12;12:730666.
• [11] Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
• [12] Antibody-Dependent Cellular Cytotoxicity Activity of a Novel Anti-PD-L1 Antibody Avelumab (MSB0010718C) on Human Tumor Cells. Cancer Immunol Res. 2015 Oct;3(10):1148-57.
• [13] Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services.
• [14] PD-1 as a potential target in cancer therapy. Cancer Med. 2013 October; 2(5): 662-673.
• [15] ClinicalTrials.gov (NCT03403777) Avelumab in Refractory Testicular Germ Cell Cancer.. U.S. National Institutes of Health.
• [16] Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health Human Services. 2019
• [17] Sugemalimab: First Approval. Drugs. 2022 Apr;82(5):593-599.
• [18] Clinical pipeline report, company report or official report of Alphamab Oncology.
• [19] National Cancer Institute Drug Dictionary (drug id 740856).
• [20] Targeted immunotherapy for non-small cell lung cancer. World J Clin Oncol. 2014 May 10; 5(2): 39-47.
• [21] GEMSTONE-301: a phase III clinical trial of CS1001 as consolidation therapy in patients with locally advanced/unresectable (stage III) non-small cell lung cancer (NSCLC) who did not have disease progression after prior concurrent/sequential chemoradiotherapy. Transl Lung Cancer Res. 2020 Oct;9(5):2008-2015.