Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMB8HCW)

Drug Name

Galnon Drug Info

Synonyms

Galnon; 475115-35-6; CHEMBL592414; 9H-fluoren-9-ylmethyl N-[(2S)-1-[[(2S)-6-amino-1-[(4-methyl-2-oxochromen-7-yl)amino]-1-oxohexan-2-yl]amino]-3-cyclohexyl-1-oxopropan-2-yl]carbamate; AC1NSKC5; SCHEMBL4464884; GTPL6118; CHEMBL451433; MolPort-023-276-322; ZINC49756387; AKOS024456937; NCGC00165798-01; B5256

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

Cross-matching ID

PubChem CID: 5311268
CAS Number: CAS 475115-35-6
TTD Drug ID: DMB8HCW

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Investigative Drug(s)

Download the Complete Related Drug List

Drug(s) Targeting Galanin receptor type 1 (GAL1-R)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
GwTLNSAGYLLGPHAVGNHRSFSDKNGLTS-CONH2	DMPIRE0	Discovery agent	N.A.	Investigative	[3]
[Sar1Gly]GAL-B2	DMUI0XV	Discovery agent	N.A.	Investigative	[3]
(Sar)WTLNSAGYLLGPKK(Lys-lauroyl)K	DMPZHIE	Discovery agent	N.A.	Investigative	[4]
GalB2	DMGX6UH	Discovery agent	N.A.	Investigative	[3]
(Sar)WTLNSAGYLLGPKK(Lys-octanoyl)K	DMX3K4E	Discovery agent	N.A.	Investigative	[4]
(Sar)WTLNSAGYLLGPKK(Lys-decanoyl)K	DMJL8SE	Discovery agent	N.A.	Investigative	[4]
(Sar)WTLNSAGYLLGPKK(Lys-MPEG4)K	DMQIHZU	Discovery agent	N.A.	Investigative	[4]
[Sar1Ala]GAL-B2	DMUD0LA	Discovery agent	N.A.	Investigative	[3]
GWTLNSAGYLLGPHAV-NH2	DMZPRIG	Discovery agent	N.A.	Investigative	[5]
GWTLNSAGYLLGPrPKPQQwFwLL-CONH2	DM48AV3	Discovery agent	N.A.	Investigative	[3]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

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Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Galanin receptor type 1 (GAL1-R)	TTX3HNZ	GALR1_HUMAN	Agonist	[2]

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References

1	URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 6118).
2	Anticonvulsant activity of a nonpeptide galanin receptor agonist. Proc Natl Acad Sci U S A. 2002 May 14;99(10):7136-41.
3	Engineering galanin analogues that discriminate between GalR1 and GalR2 receptor subtypes and exhibit anticonvulsant activity following systemic de... J Med Chem. 2010 Feb 25;53(4):1871-5.
4	Structural requirements for a lipoamino acid in modulating the anticonvulsant activities of systemically active galanin analogues. J Med Chem. 2009 Mar 12;52(5):1310-6.
5	Design, synthesis, and characterization of high-affinity, systemically-active galanin analogues with potent anticonvulsant activities. J Med Chem. 2008 Dec 25;51(24):8038-47.