Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMBRZ4P)

Drug Name

BLV-0703 Drug Info

Synonyms

BLV-200703; KTP-NH2; TAU-targeting compound (CNS disorders), Bioalvo

Indication

Disease Entry	ICD 11	Status	REF
Central nervous system disease	8A04-8D87	Investigative	[1]

Cross-matching ID

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Clinical Trial Drug(s)

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Drug(s) Targeting Microtubule-associated protein tau (MAPT)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
LMT-X	DMOFIBM	Acute myeloid leukaemia	2A60	Phase 3	[2]
Davunetide	DMD7K9X	Cognitive impairment	6D71	Phase 3	[1]
TRx0237	DM0QNF4	Alzheimer disease	8A20	Phase 3	[3]
E2814	DMZ3Q59	Alzheimer disease	8A20	Phase 2/3	[4]
PBT-2	DMKWGS1	Alzheimer disease	8A20	Phase 2	[5]
RG6100	DMEFD0B	Alzheimer disease	8A20	Phase 2	[6]
Tau-binding PET tracer	DM9QFW2	Alzheimer disease	8A20	Phase 2	[1]
BIIB092	DM263RP	Progressive supranuclear palsy	8A00.10	Phase 2	[6]
Semorinemab	DMA17VD	Alzheimer disease	8A20	Phase 2	[7]
Bepranemab	DMRQIJO	Alzheimer disease	8A20	Phase 2	[8]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

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Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Microtubule-associated protein tau (MAPT)	TTS87KH	TAU_HUMAN	Modulator	[1]

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References

1	Microtubules (tau) as an emerging therapeutic target: NAP (davunetide). Curr Pharm Des. 2011;17(31):3413-7.
2	Clinical pipeline report, company report or official report of TauRx.
3	Mechanisms of Anticholinesterase Interference with Tau Aggregation Inhibitor Activity in a Tau-Transgenic Mouse Model. Curr Alzheimer Res. 2020;17(3):285-296.
4	Pre-clinical characterisation of E2814, a high-affinity antibody targeting the microtubule-binding repeat domain of tau for passive immunotherapy in Alzheimer's disease. Acta Neuropathol Commun. 2020 Feb 4;8(1):13.
5	PBT2 rapidly improves cognition in Alzheimer's Disease: additional phase II analyses. J Alzheimers Dis. 2010;20(2):509-16.
6	Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
7	Antibody semorinemab reduces tau pathology in a transgenic mouse model and engages tau in patients with Alzheimer's disease. Sci Transl Med. 2021 May 12;13(593):eabb2639.
8	Immunotherapy for Alzheimer's disease: targeting beta-amyloid and beyond. Transl Neurodegener. 2022 Mar 18;11(1):18.