Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMBSXR9)

Drug Name

rhACE2 Drug Info

Synonyms

recombinant human ACE2; APN01

Indication

Disease Entry	ICD 11	Status	REF
Coronavirus Disease 2019 (COVID-19)	1D6Y	Phase 2	[1]

Therapeutic Class

Antiviral Agents

Cross-matching ID

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

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Drug(s) Targeting HUMAN angiotensin-converting enzyme 2 (ACE2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
N-(2-aminoethyl)-1-aziridine-ethanamine	DMRK4FA	Severe acute respiratory syndrome (SARS)	1D65	Investigative	[3]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

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Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
HUMAN angiotensin-converting enzyme 2 (ACE2)	TTYRG7F	ACE2_HUMAN	Inhibitor	[2]

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References

1	ClinicalTrials.gov (NCT04335136) Recombinant Human Angiotensin-converting Enzyme 2 (rhACE2) as a Treatment for Patients With COVID-19. U.S. National Institutes of Health.
2	ClinicalTrials.gov (NCT04287686) Recombinant Human Angiotensin-converting Enzyme 2 (rhACE2) as a Treatment for Patients With COVID-19
3	Coronaviruses - drug discovery and therapeutic options. Nat Rev Drug Discov. 2016 May;15(5):327-47.