Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMC3UYH)

Drug Name

2,3-diphenyl-1H-indole Drug Info

Synonyms

2,3-Diphenylindole; 2,3-Diphenyl-1H-indole; 3469-20-3; 1H-Indole, 2,3-diphenyl-; CHEMBL200719; GYGKJNGSQQORRG-UHFFFAOYSA-N; Indole, 2,3-diphenyl-; NSC17363; EINECS 222-432-0; Indole,3-diphenyl-; Cyto5A2; AC1Q1HUE; 1H-Indole,3-diphenyl-; AC1Q4W1P; AC1L2S6L; Oprea1_738570; 2,3-Diphenyl-1H-indole #; SCHEMBL3864662; CTK1C3291; KS-00000FNK; DTXSID50188241; MolPort-001-804-408; ZINC1036850; STK080838; BDBM50175411; RW3400; NSC-17363; CCG-46312; AKOS001022174; ACM3469203; MCULE-8938765915; VI30149; ACN-036136; 7J-655S; QC-2111; CC-07034; AK-81890

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

Cross-matching ID

PubChem CID: 77020
CAS Number: CAS 3469-20-3
TTD Drug ID: DMC3UYH

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Approved Drug(s)

Clinical Trial Drug(s)

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Drug(s) Targeting Estrogen receptor beta (ESR2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Conjugated Estrogens	DMLT0E1	Dyspareunia	GA12	Approved	[2]
Trilostane	DMQZ9GF	Cushing disease	5A70	Approved	[3]
ARZOXIFENE	DMOKCVI	Breast cancer	2C60-2C65	Approved	[4]
Estrogen	DMGY0UT	Menopause symptom	GA30.0	Approved	[5]
MF-101	DM8Z0I3	Hepatitis virus infection	1E50-1E51	Phase 3	[6]
Genistein	DM0JETC	Menopause symptom	GA30.0	Phase 2/3	[7]
AUS-131	DMUXO3Z	Hot flushes	GA30	Phase 2	[8]
ERB-041	DMCEPUA	Inflammatory bowel disease	DD72	Phase 2	[9]
Erteberel	DMU1XZD	Prostate hyperplasia	GA90	Phase 2	[10]
VG-101	DMAN21O	Menopause symptom	GA30.0	Phase 1/2	[11]
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Drug(s) Targeting Estrogen receptor (ESR)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tamoxifen	DMLB0EZ	Breast cancer	2C60-2C65	Approved	[12]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[13]
Estrone	DM5T6US	Acne vulgaris	ED80	Approved	[13]
Estradiol Valerate	DM8MC6O	Hormone replacement therapy	8E01	Approved	[3]
Estradiol Acetate	DM07U2A	Hormone replacement therapy	8E01	Approved	[3]
Estradiol Cypionate	DM27Z5T	Hormone replacement therapy	8E01	Approved	[3]
Ethinyl Estradiol	DMODJ40	Acne vulgaris	ED80	Approved	[14]
Raloxifene	DMDKF3M	Osteoporosis	FB83.0	Approved	[15]
Ospemifene	DMC4GEI	Dyspareunia	GA12	Approved	[16]
Toremifene	DMQYUWG	Breast cancer	2C60-2C65	Approved	[17]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

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Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Estrogen receptor (ESR)	TTZAYWL	ESR1_HUMAN	Inhibitor	[1]
Estrogen receptor beta (ESR2)	TTOM3J0	ESR2_HUMAN	Inhibitor	[1]

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References

1	Estrogen receptor beta selective ligands: discovery and SAR of novel heterocyclic ligands. Bioorg Med Chem Lett. 2005 Dec 15;15(24):5562-6.
2	Differential biochemical and cellular actions of Premarin estrogens: distinct pharmacology of bazedoxifene-conjugated estrogens combination. Mol Endocrinol. 2009 Jan;23(1):74-85.
3	Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services.
4	Benzothiophene selective estrogen receptor modulators with modulated oxidative activity and receptor affinity. J Med Chem. 2007 May 31;50(11):2682-92.
5	Estrogen inhibits the vascular injury response in estrogen receptor beta-deficient female mice. Proc Natl Acad Sci U S A. 1999 Dec 21;96(26):15133-6.
6	MF101, a selective estrogen receptor beta modulator for the treatment of menopausal hot flushes: a phase II clinical trial. Menopause. 2009 May-Jun;16(3):458-65.
7	Company report (Axcentua)
8	S-equol, a potent ligand for estrogen receptor beta, is the exclusive enantiomeric form of the soy isoflavone metabolite produced by human intestinal bacterial flora. Am J Clin Nutr. 2005 May;81(5):1072-9.
9	Erb-041, an estrogen receptor-beta agonist, inhibits skin photocarcinogenesis in SKH-1 hairless mice by downregulating the WNT signaling pathway. Cancer Prev Res (Phila). 2014 Feb;7(2):186-98.
10	Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800031986)
11	Update on alternative therapies for vulvovaginal atrophy. Patient Prefer Adherence. 2011; 5: 533-536.
12	Modulators of vascular sex hormone receptors and their effects in estrogen-deficiency states associated with menopause. Recent Pat Cardiovasc Drug Discov. 2008 Nov;3(3):165-86.
13	Reprint of Are all estrogens the same Maturitas. 2008 Sep-Oct;61(1-2):195-201.
14	17alpha-Ethinylestradiol hinders nucleotide excision repair in zebrafish liver cells. Aquat Toxicol. 2009 Dec 13;95(4):273-8.
15	URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 620).
16	Clinical pipeline report, company report or official report of Shionogi (2011).
17	Effect of selective estrogen receptor modulators on cell proliferation and estrogen receptor activities in normal human prostate stromal and epithe... Prostate Cancer Prostatic Dis. 2009;12(4):375-81.