Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMC87DR)

Drug Name

GLPG-0259 Drug Info

Synonyms

G-13919, GT-146, GT-1498, GT-1704, GT-314, GT-416, GT-514, GT-562

Indication

Disease Entry	ICD 11	Status	REF
Rheumatoid arthritis	FA20	Discontinued in Phase 2	[1]

Cross-matching ID

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Investigative Drug(s)

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Drug(s) Targeting MAPK-activated protein kinase 5 (MAPKAPK5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
PMID17480064C16	DM4IABG	Discovery agent	N.A.	Investigative	[3]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

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Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
MAPK-activated protein kinase 5 (MAPKAPK5)	TT3UJ7Z	MAPK5_HUMAN	Inhibitor	[2]

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References

1	Clinical pipeline report, company report or official report of Galapagos.
2	URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 2096).
3	Pyrrolopyridine inhibitors of mitogen-activated protein kinase-activated protein kinase 2 (MK-2). J Med Chem. 2007 May 31;50(11):2647-54.