Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMCFGD4)

Drug Name

TM38837 Drug Info

Synonyms

TM-38837; compound 8; CHEMBL3341897; 1253641-65-4; TM38837; GTPL8705; SCHEMBL16127787; BCP24151; BDBM50044129; AKOS030525391; 1-(2,4-dichlorophenyl)-4-ethyl-N-piperidin-1-yl-5-[5-[2-[4-(trifluoromethyl)phenyl]ethynyl]thiophen-2-yl]pyrazole-3-carboxamide; 1-(2,4-Dichlorophenyl)-4-ethyl-N-(piperidin-1-yl)-5-(5-((4-(trifluoromethyl)phenyl)ethynyl)thiophen-2-yl)-1H-pyrazole-3-carboxamide

Indication

Disease Entry	ICD 11	Status	REF
Metabolic disorder	5C50-5D2Z	Phase 1	[1]
Obesity	5B81	Phase 1	[1]

Cross-matching ID

PubChem CID: 49779607
TTD Drug ID: DMCFGD4

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Approved Drug(s)

Clinical Trial Drug(s)

Download the Complete Related Drug List

Drug(s) Targeting Cannabinoid receptor 1 (CB1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[3]
NABILONE	DMVRYT2	Insomnia	7A00-7A0Z	Approved	[4]
Orlistat	DMRJSP8	Obesity	5B81	Approved	[5]
SR141716A	DMCO5JZ	Obesity	5B81	Approved	[6]
Tebipenem	DMVSX6O	Urinary tract infection	GC08	Phase 3	[7]
Conatumumab	DM2UOSN	Colorectal cancer	2B91.Z	Phase 2	[8]
GW-42004	DMY3KSU	Lipid metabolism disorder	5C52.Z	Phase 2	[9]
SR-147778	DMNAECP	Obesity	5B81	Phase 2	[10]
Nimacimab	DM21Z68	Diabetic nephropathy	GB61.Z	Phase 2	[11]
AEF0117	DMQ1GH4	Marijuana use disorder	6C41	Phase 2	[12]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

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Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Cannabinoid receptor 1 (CB1)	TT6OEDT	CNR1_HUMAN	Antagonist	[2]

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References

1	URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 8705).
2	2011 Pipeline of 7TM Pharma.
3	Emerging strategies for exploiting cannabinoid receptor agonists as medicines. Br J Pharmacol. 2009 Feb;156(3):397-411.
4	Novel 1',1'-chain substituted hexahydrocannabinols: 9-hydroxy-3-(1-hexyl-cyclobut-1-yl)-hexahydrocannabinol (AM2389) a highly potent cannabinoid r... J Med Chem. 2010 Oct 14;53(19):6996-7010.
5	Tetrahydrolipstatin analogues as modulators of endocannabinoid 2-arachidonoylglycerol metabolism. J Med Chem. 2008 Nov 13;51(21):6970-9.
6	Anti-obesity drugs. Expert Opin Pharmacother. 2008 Jun;9(8):1339-50.
7	Emerging drugs for obesity: linking novel biological mechanisms to pharmaceutical pipelines. Expert Opin Emerg Drugs. 2005 Aug;10(3):643-60.
8	Clinical pipeline report, company report or official report of AstraZeneca (2009).
9	Company report (Gwpharm)
10	Surinabant, a selective cannabinoid receptor type 1 antagonist, inhibits 9-tetrahydrocannabinol-induced central nervous system and heart rate effects in humans.Br J Clin Pharmacol.2013 Jul;76(1):65-77.
11	Clinical pipeline report, company report or official report of Bird Rock Bio.
12	Clinical pipeline report, company report or official report of Affimed Therapeutics.