Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMCIZ7P)

• Drug Name: (S)-5-fluorowillardiine Drug Info
• Synonyms: 5-Fluorowillardiine; (S)-(-)-5-fluorowillardiine; 140187-23-1; FLUORO-WILLARDIINE; (S)-F-Willardiine; (S)-5-FLUOROWILLARDIINE; 2-AMINO-3-(5-FLUORO-2,4-DIOXO-3,4-DIHYDRO-2H-PYRIMIDIN-1-YL)-PROPIONIC ACID; CHEMBL123132; CHEBI:42549; 3-(5-fluoro-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-L-alanine; (S)-alpha-Amino-5-fluoro-3,4-dihydro-2,4-dioxo-1(2H)-pyrimmidinepropanoic acid; 3-(5-fluorouracil-1-yl)-L-alanine; (2S)-2-amino-3-(5-fluoro-2,4-dioxo-1,2,3,4-tetrahydropyrimidin-1-yl)propanoic acid; (S)-(-)-5-fluorowillardine

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

• Cross-matching ID:
  PubChem CID: 126569
  ChEBI ID: CHEBI:42549
  CAS Number: CAS 140187-23-1
  TTD Drug ID: DMCIZ7P

Molecule-Related Drug Atlas

Drug(s) Targeting Glutamate receptor AMPA 1 (GRIA1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
E-2007	DMJDYNQ	Diabetic neuropathy	8C0Z	Approved	[6]
NBQX	DMPHZI5	Neurological disorder	6B60	Phase 1	[7]
YM-90K	DMWRT4L	Convulsion	8A68.Z	Discontinued in Phase 2	[8]
Farampator	DM76GRQ	Major depressive disorder	6A70.3	Discontinued in Phase 1	[9]
GYKI-52466	DM3YG5P	Alzheimer disease	8A20	Terminated	[10]
GYKI-53655	DMC0JN8	N. A.	N. A.	Terminated	[11]
Zonampanel	DM70HZD	N. A.	N. A.	Terminated	[8]
SORETOLIDE	DMTDLHG	Convulsion	8A68.Z	Terminated	[12]
[3H]kainate	DMMK7XU	Discovery agent	N.A.	Investigative	[13]
DNQX	DMQXPA5	Discovery agent	N.A.	Investigative	[14]

Drug(s) Targeting Glutamate receptor AMPA 2 (GRIA2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
E-2007	DMJDYNQ	Diabetic neuropathy	8C0Z	Approved	[6]
Paliroden	DMX8ZAQ	Parkinson disease	8A00.0	Phase 2	[15]
[3H]CNQX	DMIFKUX	Discovery agent	N.A.	Investigative	[3]
ATPO	DMXLS78	Discovery agent	N.A.	Investigative	[3]
[3H]AMPA	DMLF7SG	N. A.	N. A.	Investigative	[3]

Drug(s) Targeting Glutamate receptor AMPA 3 (GRIA3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
E-2007	DMJDYNQ	Diabetic neuropathy	8C0Z	Approved	[6]
[3H]CNQX	DMIFKUX	Discovery agent	N.A.	Investigative	[4]
ATPO	DMXLS78	Discovery agent	N.A.	Investigative	[4]
[3H]AMPA	DMLF7SG	N. A.	N. A.	Investigative	[4]
joro toxin	DMYBJ4K	Discovery agent	N.A.	Investigative	[4]

Drug(s) Targeting Glutamate receptor AMPA 4 (GRIA4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
E-2007	DMJDYNQ	Diabetic neuropathy	8C0Z	Approved	[6]
[3H]CNQX	DMIFKUX	Discovery agent	N.A.	Investigative	[5]
ATPO	DMXLS78	Discovery agent	N.A.	Investigative	[5]
[3H]AMPA	DMLF7SG	N. A.	N. A.	Investigative	[5]
joro toxin	DMYBJ4K	Discovery agent	N.A.	Investigative	[5]
AMG-889436	DMKP8L9	Parkinson disease	8A00.0	Investigative	[5]

Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Glutamate receptor AMPA 1 (GRIA1)	TTVPQTF	GRIA1_HUMAN	Agonist	[2]
Glutamate receptor AMPA 2 (GRIA2)	TT9HLZ0	GRIA2_HUMAN	Agonist	[3]
Glutamate receptor AMPA 3 (GRIA3)	TT82EZV	GRIA3_HUMAN	Agonist	[4]
Glutamate receptor AMPA 4 (GRIA4)	TTPJR0G	GRIA4_HUMAN	Agonist	[5]

References

• [1] URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 4070).
• [2] URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 444).
• [3] URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 445).
• [4] URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 446).
• [5] URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 447).
• [6] Antibodies and venom peptides: new modalities for ion channels. Nat Rev Drug Discov. 2019 May;18(5):339-357.
• [7] Structural investigation of the 7-chloro-3-hydroxy-1H-quinazoline-2,4-dione scaffold to obtain AMPA and kainate receptor selective antagonists. Syn... J Med Chem. 2006 Oct 5;49(20):6015-26.
• [8] Synthesis and AMPA receptor antagonistic activity of a novel 7-imidazolyl-6-trifluoromethyl quinoxalinecarboxylic acid with a substituted phenyl gr... Bioorg Med Chem Lett. 2004 Oct 18;14(20):5107-11.
• [9] The pipeline and future of drug development in schizophrenia. Mol Psychiatry. 2007 Oct;12(10):904-22.
• [10] New 7,8-ethylenedioxy-2,3-benzodiazepines as noncompetitive AMPA receptor antagonists. Bioorg Med Chem Lett. 2006 Jan 1;16(1):167-70.
• [11] Substituted 1,2-dihydrophthalazines: potent, selective, and noncompetitive inhibitors of the AMPA receptor. J Med Chem. 1996 Jan 19;39(2):343-6.
• [12] Preclinical pharmacology of perampanel, a selective non-competitive AMPA receptor antagonist. Acta Neurol Scand Suppl. 2013;(197):19-24.
• [13] 1H-cyclopentapyrimidine-2,4(1H,3H)-dione-related ionotropic glutamate receptors ligands. structure-activity relationships and identification of pot... J Med Chem. 2008 Oct 23;51(20):6614-8.
• [14] Synthesis of chiral 1-(2'-amino-2'-carboxyethyl)-1,4-dihydro-6,7-quinoxaline-2,3-diones: alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionate recep... J Med Chem. 1996 Oct 25;39(22):4430-8.
• [15] Mechanism of inhibition of the GluA2 AMPA receptor channel opening by talampanel and its enantiomer: the stereochemistry of the 4-methyl group on the diazepine ring of 2,3-benzodiazepine derivatives.ACS Chem Neurosci.2013 Apr 17;4(4):635-44.