Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMCK210)

Drug Name

XR-9051 Drug Info

Synonyms

Multidrug resistance inhibitor, Xenova

Indication

Disease Entry	ICD 11	Status	REF
Solid tumour/cancer	2A00-2F9Z	Discontinued in Phase 1	[1]

Cross-matching ID

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Discontinued Drug(s)

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Drug(s) Targeting P-glycoprotein (P-GP)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
S-9788	DMER3I9	Solid tumour/cancer	2A00-2F9Z	Discontinued in Phase 2	[3]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

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Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Multidrug resistance protein 1 (ABCB1)	TT3OT40	MDR1_HUMAN	Inhibitor	[2]
P-glycoprotein (P-GP)	TTO32GK	NOUNIPROTAC	Inhibitor	[2]

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References

1	Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800007052)
2	Communication between multiple drug binding sites on P-glycoprotein. Mol Pharmacol. 2000 Sep;58(3):624-32.
3	In vitro activity of S 9788 on a multidrug-resistant leukemic cell line and on normal hematopoietic cells-reversal of multidrug resistance by sera from phase I-treated patients. Cancer Chemother Pharmacol. 1995;36(3):195-203.