Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMCMIUG)

Drug Name

SITS Drug Info

Synonyms

4'-isothiocyanostilbene-2,2'-disulphonic acid

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

Cross-matching ID

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Approved Drug(s)

Investigative Drug(s)

Download the Complete Related Drug List

Drug(s) Targeting Calcium-dependent chloride channel anoctamin (ANO)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Benzbromarone	DMC3YUA	Gout	FA25	Approved	[4]
Crofelemer	DM4AMQZ	HIV-associated diarrhoea	1A2Z	Approved	[5]
NPPB	DMFIWAN	Discovery agent	N.A.	Investigative	[2]
DIDS	DMKSQUB	Discovery agent	N.A.	Investigative	[2]
9-anthroic acid	DMGCVT2	Discovery agent	N.A.	Investigative	[2]
DCDPC	DMG9BFR	Discovery agent	N.A.	Investigative	[2]
tannic acid	DM52WGH	Discovery agent	N.A.	Investigative	[2]
Ins(3,4,5,6)P4	DMAQU71	Discovery agent	N.A.	Investigative	[2]
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⏷ Show the Full List of 8 Drug(s)

Drug(s) Targeting Chloride channel protein 7 (ClC-7)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
NPPB	DMFIWAN	Discovery agent	N.A.	Investigative	[6]
DIDS	DMKSQUB	Discovery agent	N.A.	Investigative	[6]
diphenylamine-2-carboxylic acid	DMBV19T	Discovery agent	N.A.	Investigative	[3]
GTPgammaS	DMJUXKY	Discovery agent	N.A.	Investigative	[3]
NS5818	DM629TD	Discovery agent	N.A.	Investigative	[6]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Calcium-dependent chloride channel anoctamin (ANO)	TTOJI4S	ANO1_HUMAN	Blocker (channel blocker)	[2]
Chloride channel protein 7 (ClC-7)	TTST1AJ	CLCN7_HUMAN	Blocker (channel blocker)	[3]

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References

1	URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 4314).
2	URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 708).
3	URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 709).
4	Anoctamin Channels in Human Myometrium: A Novel Target for Tocolysis.Reprod Sci. 2018 Nov;25(11):1589-1600.
5	Nat Rev Drug Discov. 2013 Feb;12(2):87-90.
6	The G215R mutation in the Cl-/H+-antiporter ClC-7 found in ADO II osteopetrosis does not abolish function but causes a severe trafficking defect. PLoS One. 2010 Sep 7;5(9):e12585.