Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMCN91V)

Drug Name

MI-1148 Drug Info

Synonyms

4-guanidinomethyl-phenylacteyl-Arg-Tle-Arg-4-amidinobenzylamide; para-guanidinomethyl-Phac-R-Tle-R-Amba

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

Cross-matching ID

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Patented Agent(s)

Preclinical Drug(s)

Investigative Drug(s)

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Drug(s) Targeting Dibasic-processing enzyme (Furin)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
US9266828, E	DMYUL2X	N. A.	N. A.	Patented	[2]
US9266828, C	DMQEL1W	N. A.	N. A.	Patented	[2]
US9266828, B	DMYUDCE	N. A.	N. A.	Patented	[2]
DecRVKRCMK	DMAUILH	Coronavirus infection	1D92	Preclinical	[3]
furin inhibitor peptide	DM78NOM	Discovery agent	N.A.	Investigative	[4]
peptide 18	DMIDP1R	Discovery agent	N.A.	Investigative	[5]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

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Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Dibasic-processing enzyme (Furin)	TTH9WF6	FURIN_HUMAN	Inhibitor	[1]

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References

1	Novel Furin Inhibitors with Potent Anti-infectious Activity. ChemMedChem. 2015 Jul;10(7):1218-31.
2	Inhibitors of Furin and other pro-protein convertases. US9266828.
3	Decanoyl-Arg-Val-Lys-Arg-Chloromethylketone: An Antiviral Compound That Acts against Flaviviruses through the Inhibition of Furin-Mediated prM Cleavage. Viruses. 2019 Oct 31;11(11):1011.
4	Targeting host cell furin proprotein convertases as a therapeutic strategy against bacterial toxins and viral pathogens. J Biol Chem. 2007 Jul 20;282(29):20847-53.
5	Design, synthesis, and structure-activity relationship studies of a potent PACE4 inhibitor. J Med Chem. 2014 Jan 9;57(1):98-109.