Details of the Drug-Related molecule(s) Interaction Atlas

DACTHF Drug Info

Deazaacyclotetrahydrofolate; 5-deazaacyclotetrahydrofolate; 5-DACTHF

Cross-matching ID

TTD Drug ID

DMCNAME

INTEDE Drug ID

DR0019

General Information of Drug (ID: DMCNAME)

Molecule-Related Drug Atlas

Molecule Type:

DME

Drug Status:

Approved Drug(s)

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Drug(s) Metabolized By Folylpolyglutamate synthase (FPGS)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[2]
Pralatrexate	DMAO80I	Breast cancer	2C60-2C65	Approved	[3]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

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Drug-Metabolizing Enzyme (DME)

DME Name	DME ID	UniProt ID	MOA	REF
Folylpolyglutamate synthase (FPGS)^{Main DME}	DECWT2V	FOLC_HUMAN	Substrate	[1]

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References

1	Role of folylpolyglutamate synthetase in the metabolism and cytotoxicity of 5-deazaacyclotetrahydrofolate, an anti-purine drug. J Biol Chem. 1994 Apr 1;269(13):9714-20.
2	The pharmacogenetics of methotrexate. Rheumatology (Oxford). 2007 Oct;46(10):1520-4.
3	Pralatrexate : evaluation of clinical efficacy and toxicity in T-cell lymphoma. Expert Opin Pharmacother. 2013 Mar;14(4):515-23.