Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMCNTFW)

Drug Name

Ad-RTS-hIL-12 Drug Info

Indication

Disease Entry	ICD 11	Status	REF
Glioblastoma of brain	2A00.00	Phase 2	[1]
Melanoma	2C30	Phase 2	[2]
Recurrent glioblastoma	2A00.00	Phase 2	[3]
Malignant glioma	2A00.0	Phase 1	[4]

Cross-matching ID

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Clinical Trial Drug(s)

Investigative Drug(s)

Download the Complete Related Drug List

Drug(s) Targeting Interleukine 12 (IL-12)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
ABP 654	DM0GXWT	Plaque psoriasis	EA90.0	Phase 3	[6]
GEN-1	DMJN09S	Ovarian cancer	2C73	Phase 2	[7]
Tavokinogene telseplasmid	DMZX0VF	Melanoma	2C30	Phase 2	[8]
MEDI1191	DMD9OVI	Solid tumour/cancer	2A00-2F9Z	Phase 1	[9]
M9241	DMZUM67	Pancreatic cancer	2C10	Phase 1	[10]
YH010	DMA1T66	Aggressive cancer	2A00-2F9Z	Investigative	[11]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

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Drug Therapeutic Target (DTT)

References

1	ClinicalTrials.gov (NCT04006119) Study of Ad-RTS-hIL-12 + Veledimex in Combination With Cemiplimab in Subjects With Recurrent or Progressive Glioblastoma. U.S. National Institutes of Health.
2	Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800033476)
3	Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
4	Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
5	Clinical pipeline report, company report or official report of Ziopharm Oncology.
6	Clinical pipeline report, company report or official report of Amgen
7	Clinical pipeline report, company report or official report of Celsion.
8	Intratumoral delivery of tavokinogene telseplasmid yields systemic immune responses in metastatic melanoma patients. Ann Oncol. 2020 Apr;31(4):532-540.
9	Intratumoral IL12 mRNA Therapy Promotes TH1 Transformation of the Tumor Microenvironment. Clin Cancer Res. 2020 Dec 1;26(23):6284-6298.
10	Clinical pipeline report, company report or official report of EMD Serono.
11	Clinical pipeline report, company report or official report of Biocytogen