Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMCOLUP)

Drug Name

Levallorphan Drug Info

Synonyms

Levallofano; Levallorphane; Levallorphanum; Levalorfano; Naloxiphan; Levallofano [DCIT]; Levallorphan [INN:BAN]; Levallorphane [INN-French]; Levallorphanum [INN-Latin]; Levalorfano [INN-Spanish]; Lorfan (TN); Ro-1-7700; N-Allyl-3-hydroxymorphinan; L-N-Allyl-3-hydroxymorphinan; Levo-3-hydroxy-N-allyl morphinan; (-)-3-Hydroxy-N-allylmorphinan; 17-Allylmorphinan-3-ol; 17-prop-2-en-1-ylmorphinan-3-ol

Indication

Disease Entry	ICD 11	Status	REF
Narcotic depression	6A7Z	Approved	[1]

Therapeutic Class

Antinarcotic Agents

Cross-matching ID

PubChem CID: 5359371
ChEBI ID: CHEBI:6431
CAS Number: CAS 152-02-3
TTD Drug ID: DMCOLUP

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Approved Drug(s)

Clinical Trial Drug(s)

Investigative Drug(s)

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Drug(s) Targeting Neuronal acetylcholine receptor alpha-2 (CHRNA2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Rocuronium	DMY9BMK	Muscle spasm	MB47.3	Approved	[3]
Tubocurarine	DMBZIVP	Anaesthesia	9A78.6	Approved	[3]
Cisatracurium	DMUZPJ5	Muscle spasm	MB47.3	Approved	[3]
Vecuronium	DMP0UK2	Spasm	MB47.3	Approved	[3]
Mivacurium	DM473VD	Anaesthesia	9A78.6	Approved	[3]
Carbachol	DMX9K8F	Glaucoma/ocular hypertension	9C61	Approved	[2]
Pipecuronium	DM5F84A	Spasm	MB47.3	Approved	[2]
CYTISINE	DMUF0BJ	Tobacco dependence	6C4A.2	Phase 3	[4]
CHOLINE	DM5D9YK	Insomnia	7A00-7A0Z	Investigative	[5]
[125I]epibatidine	DMZWQH3	Discovery agent	N.A.	Investigative	[6]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

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Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Neuronal acetylcholine receptor alpha-2 (CHRNA2)	TTF4E0J	ACHA2_HUMAN	Antagonist	[2]

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References

1	URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 7209).
2	Synergy between pairs of competitive antagonists at adult human muscle acetylcholine receptors. Anesth Analg. 2008 Aug;107(2):525-33.
3	Pharmacological characteristics of the inhibition of nondepolarizing neuromuscular blocking agents at human adult muscle nicotinic acetylcholine receptor. Anesthesiology. 2009 Jun;110(6):1244-52.
4	Synthesis and pharmacological evaluation of novel 9- and 10-substituted cytisine derivatives. Nicotinic ligands of enhanced subtype selectivity. J Med Chem. 2006 May 4;49(9):2673-6.
5	Pharmacology of the agonist binding sites of rat neuronal nicotinic receptor subtypes expressed in HEK 293 cells. Bioorg Med Chem Lett. 2004 Apr 19;14(8):1845-8.
6	URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 463).