Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMCQHG4)

Drug Name

FR-183998 Drug Info

Synonyms

FR-183998; AC1OCFC6; SCHEMBL6134503; 3-N-(diaminomethylidene)-5-(2,5-dichlorothiophen-3-yl)-1-N-(2-dimethylaminoethyl)benzene-1,3-dicarboxamide dihydrochloride; 3-(2,5-dichlorothiophen-3-yl)-N-[2-(dimethylamino)ethyl]-5-guanidinocarbonylbenzamide dihydrochloride

Indication

Disease Entry	ICD 11	Status	REF
Hypertension	BA00-BA04	Terminated	[1]

Cross-matching ID

PubChem CID: 6918360
TTD Drug ID: DMCQHG4

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Investigative Drug(s)

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Drug(s) Targeting Sodium/hydrogen exchanger (SLC)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Rimeporide	DM59G40	Myocardial infarction	BA41-BA43	Investigative	[3]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Sodium/hydrogen exchanger (SLC)	TT70SZ3	NOUNIPROTAC	Modulator	[2]

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References

1	Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800009190)
2	Protective effect of FR183998, a Na+/H+ exchanger inhibitor, and its inhibition of iNOS induction in hepatic ischemia-reperfusion injury in rats. Shock. 2008 Sep;30(3):311-7.
3	Sodium-hydrogen exchanger, cardiac overload, and myocardial hypertrophy. Circulation. 2007 Mar 6;115(9):1090-100.