Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMCVXBE)

Drug Name
E-64D Drug Info
Synonyms
E64D; E64d; Aloxistatin; Aloxistatin [INN]; Aloxistatina; Aloxistatina [Spanish]; Aloxistatine; Aloxistatine [French]; Aloxistatinum; Aloxistatinum [Latin]; BRN 5354546; C17H30N2O5; CCRIS 1934; CHEMBL63440; E 64c ethyl ester; E 64d; EP 453; EST; EST (pharmaceutical); L5W337AOUR; Loxistatin; MLS000028372; NSC 694281; SMR000058552; UNII-L5W337AOUR
Indication
Disease Entry ICD 11 Status REF
Middle East Respiratory Syndrome (MERS) 1D64 Preclinical [1]
Severe acute respiratory syndrome (SARS) 1D65 Preclinical [1]
Therapeutic Class
Antiviral Agents
Cross-matching ID
PubChem CID
65663
ChEBI ID
CHEMBL63440
CAS Number
CAS 88321-09-9
TTD Drug ID
DMCVXBE

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
DOT
Drug Status:
Approved Drug(s)
Download the Complete Related Drug List
Drug(s) Targeting HUMAN cathepsin L (CTSL)
Drug Name Drug ID Indication ICD 11 Highest Status REF
PMID26868298-compound-5705213 DMZMYU5 Middle East Respiratory Syndrome (MERS) 1D64 Preclinical [1]
K11777 DM86YBK Middle East Respiratory Syndrome (MERS) 1D64 Preclinical [1]
Drug(s) Affected By Microtubule-associated proteins 1A/1B light chain 3B (MAP1LC3B)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [2]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [3]
Methotrexate DM2TEOL Anterior urethra cancer Approved [4]
Quercetin DM3NC4M Obesity 5B81 Approved [5]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [6]
Nefazodone DM4ZS8M Major depressive disorder 6A70.3 Approved [7]
Rifampicin DM5DSFZ Non-insulin dependent diabetes 5A11 Approved [8]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [9]
Trovafloxacin DM6AN32 Acute gonococcal cervicitis Approved [10]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [11]
⏷ Show the Full List of 10 Drug(s)

Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas
Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
HUMAN cathepsin L (CTSL) TTS586L CATL1_HUMAN Blocker [1]

Drug Off-Target (DOT)
DOT Name DOT ID UniProt ID Interaction REF
Microtubule-associated proteins 1A/1B light chain 3B (MAP1LC3B) OTUYHB84 MLP3B_HUMAN Post-Translational Modifications [2]

References

1 Coronaviruses - drug discovery and therapeutic options. Nat Rev Drug Discov. 2016 May;15(5):327-47.
2 Antidepressant drug sertraline modulates AMPK-MTOR signaling-mediated autophagy via targeting mitochondrial VDAC1 protein. Autophagy. 2021 Oct;17(10):2783-2799. doi: 10.1080/15548627.2020.1841953. Epub 2020 Nov 9.
3 Repression of Kisspeptin1 weakens hydrogen peroxide-caused injury in HTR8 cells via adjusting PI3K/AKT/mTOR pathway. J Biochem Mol Toxicol. 2020 May;34(5):e22461. doi: 10.1002/jbt.22461. Epub 2020 Feb 11.
4 Functional gene expression profile underlying methotrexate-induced senescence in human colon cancer cells. Tumour Biol. 2011 Oct;32(5):965-76.
5 Comparison of phenotypic and transcriptomic effects of false-positive genotoxins, true genotoxins and non-genotoxins using HepG2 cells. Mutagenesis. 2011 Sep;26(5):593-604.
6 Low Autophagy (ATG) Gene Expression Is Associated with an Immature AML Blast Cell Phenotype and Can Be Restored during AML Differentiation Therapy. Oxid Med Cell Longev. 2018 Mar 18;2018:1482795. doi: 10.1155/2018/1482795. eCollection 2018.
7 Robustness testing and optimization of an adverse outcome pathway on cholestatic liver injury. Arch Toxicol. 2020 Apr;94(4):1151-1172. doi: 10.1007/s00204-020-02691-9. Epub 2020 Mar 10.
8 Inhibitory effect of PXR on ammonia-induced hepatocyte autophagy via P53. Toxicol Lett. 2018 Oct 1;295:153-161. doi: 10.1016/j.toxlet.2018.06.1066. Epub 2018 Jun 14.
9 Arsenic trioxide induces autophagic cell death in osteosarcoma cells via the ROS-TFEB signaling pathway. Biochem Biophys Res Commun. 2018 Jan 29;496(1):167-175. doi: 10.1016/j.bbrc.2018.01.018. Epub 2018 Jan 4.
10 TNF enhances trovafloxacin-induced in vitro hepatotoxicity by inhibiting protective autophagy. Toxicol Lett. 2021 May 15;342:73-84. doi: 10.1016/j.toxlet.2021.02.009. Epub 2021 Feb 17.
11 Hydroquinone-induced endoplasmic reticulum stress affects TK6 cell autophagy and apoptosis via ATF6-mTOR. Environ Toxicol. 2023 Aug;38(8):1874-1890. doi: 10.1002/tox.23814. Epub 2023 May 6.