Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMD0NA1)

• Drug Name: TP 6076 Drug Info

Indication

Disease Entry	ICD 11	Status	REF
Multidrug resistant infection	MG51	Phase 1	[1]

• Cross-matching ID: TTD Drug ID: DMD0NA1

Molecule-Related Drug Atlas

Drug(s) Targeting Bacterial 30S ribosomal RNA (Bact 30S rRNA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Nitrofurazone	DMSM2KE	Skin burns	ME65.0	Approved	[3]
Gentamicin	DMKINJO	Bacteremia	1A73	Approved	[4]
Tobramycin	DMUI0CH	Bacteremia	1A73	Approved	[5]
TP-434	DM5A31S	Intra-abdominal infection	1A40	Approved	[6]
Doxycycline	DM7ICNU	Acne vulgaris	ED80	Approved	[4]
Omadacycline	DMR2J95	Acute bacterial skin infection	1C41	Approved	[7]
Sarecycline	DMLZNIQ	Acne vulgaris	ED80	Approved	[8]
ME1100	DM39PSZ	Bacterial pneumonia	CA40.0	Phase 1	[9]
TP-6076	DM5RIT8	Enterobacteriaceae infection	MG50.C	Phase 1	[2]
TP-271	DM3PJSE	Pneumonia	CA40	Phase 1	[10]

Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Bacterial 30S ribosomal RNA (Bact 30S rRNA)	TTOVFH2	NOUNIPROTAC	Inhibitor	[2]

References

• [1] ClinicalTrials.gov (NCT03691584) Phase 1, Safety and Bronchopulmonary PK Study in Healthy Volunteers (BAL). U.S. National Institutes of Health.
• [2] Clinical pipeline report, company report or official report of Tetraphase Pharmaceuticals.
• [3] The antibiotic Furvina targets the P-site of 30S ribosomal subunits and inhibits translation initiation displaying start codon bias. Nucleic Acids Res. 2012 Nov 1;40(20):10366-74.
• [4] Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services.
• [5] Mechanism of action of aminoglycoside antibiotics.Binding studies of tobramycin and its 6'-N-acetyl derivative to the bacterial ribosome and its subunits.Eur J Biochem.1979 Dec;102(1):73-81.
• [6] The antibiotic arms race: current and emerging therapy for Klebsiella pneumoniae carbapenemase (KPC) - producing bacteria.Expert Opin Pharmacother. 2018 Oct 22:1-13.
• [7] Omadacycline Enters the Ring: A New Antimicrobial Contender.Pharmacotherapy. 2018 Dec;38(12):1194-1204.
• [8] Microbiological Profile of Sarecycline, a Novel Targeted Spectrum Tetracycline for the Treatment of Acne Vulgaris.Antimicrob Agents Chemother. 2018 Dec 21;63(1). pii: e01297-18.
• [9] ClinicalTrials.gov (NCT01961830) Intrapulmonary Pharmacokinetics of ME1100 in Healthy Volunteers. U.S. National Institutes of Health.
• [10] Clinical pipeline report, company report or official report of Tetraphase Pharmaceuticals.