Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMD6UC9)

• Drug Name: 7alpha-Cl-ginkgolide B Drug Info
• Synonyms: 7alpha-Cl-ginkgolide B; 7alpha-Cl-GB

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

• Cross-matching ID:
  PubChem CID: 73755014
  TTD Drug ID: DMD6UC9

Molecule-Related Drug Atlas

Drug(s) Targeting Platelet-activating factor receptor (PTAFR)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ticlopidine	DMO946V	Acute coronary syndrome	BA41	Approved	[3]
RUPATADINE	DMBPN7T	N. A.	N. A.	Phase 4	[4]
ISRAPAFANT	DMP61YB	Asthma	CA23	Phase 3	[5]
CMI-392	DM1NCUY	Psoriasis vulgaris	EA90	Phase 2	[6]
Lexipafant	DMZ2YBE	Nerve injury	ND56.4	Phase 2	[7]
YM-264	DMAZNVX	Sepsis	1G40-1G41	Phase 2	[8]
Dersalazine	DMH96JW	Inflammatory bowel disease	DD72	Phase 2	[9]
60P002	DMHBN8X	Dengue	1D20-1D2Z	Phase 2	[10]
PegCNTF	DMW7VGZ	Obesity	5B81	Phase 1	[11]
FOROPAFANT	DML1DGP	Asthma	CA23	Discontinued in Phase 3	[12]

Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Platelet-activating factor receptor (PTAFR)	TTQL5VC	PTAFR_HUMAN	Antagonist	[2]

References

• [1] URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 1840).
• [2] Preparation of 7-substituted ginkgolide derivatives: potent platelet activating factor (PAF) receptor antagonists. J Med Chem. 2003 Feb 13;46(4):601-8.
• [3] Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services.
• [4] Designed multiple ligands. An emerging drug discovery paradigm. J Med Chem. 2005 Oct 20;48(21):6523-43.
• [5] Amino acid residues critical for endoplasmic reticulum export and trafficking of platelet-activating factor receptor. J Biol Chem. 2010 Feb 19;285(8):5931-40.
• [6] Anti-inflammatory activities of LDP-392, a dual PAF receptor antagonist and 5-lipoxygenase inhibitor. Pharmacol Res. 2001 Sep;44(3):213-20.
• [7] Lexipafant and acute pancreatitis: a critical appraisal of the clinical trials.Eur J Surg.2002;168(4):215-9.
• [8] Effects of YM264, a novel PAF antagonist, on puromycin aminonucleoside-induced nephropathy in the rat. Biochem Biophys Res Commun. 1991 Apr 30;176(2):781-5.
• [9] The intestinal anti-inflammatory effect of dersalazine sodium is related to a down-regulation in IL-17 production in experimental models of rodent colitis. Br J Pharmacol. 2012 February; 165(3): 729-740.
• [10] Clinical pipeline report, company report or official report of 60 Degrees Pharmaceuticals.
• [11] Sch 37370: a new drug combining antagonism of platelet-activating factor (PAF) with antagonism of histamine. Agents Actions Suppl. 1991;34:313-21.
• [12] Biochemical and pharmacological activities of SR 27417, a highly potent, long-acting platelet-activating factor receptor antagonist. J Pharmacol Exp Ther. 1991 Oct;259(1):44-51.