Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMDCZWY)

Drug Name

gamma-butyrolactone Drug Info

Synonyms

4-butanolide; 2-oxolanone

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

Cross-matching ID

Molecule-Related Drug Atlas

Molecule Type:

DME

Drug Status:

Approved Drug(s)

Clinical Trial Drug(s)

Investigative Drug(s)

Download the Complete Related Drug List

Drug(s) Metabolized By Serum paraoxonase/arylesterase 1 (PON1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Loteprednol Etabonate	DM8QTJI	Eye inflammation	9A02	Approved	[3]
Prulifloxacin	DMOK965	Urinary tract infection	GC08	Approved	[4]
RTR-003632	DM45NHF	N. A.	N. A.	Phase 2	[2]
PARAOXON	DMN4ZKC	Discovery agent	N.A.	Investigative	[2]
Coumaranone	DM7TCPG	N. A.	N. A.	Investigative	[2]
Dihydrocoumarin	DMGLX1R	N. A.	N. A.	Investigative	[2]
Gamma-thiobutyrolactone	DM83HUI	N. A.	N. A.	Investigative	[2]
Homogentisic acid	DMQD0YW	N. A.	N. A.	Investigative	[2]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

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Drug-Metabolizing Enzyme (DME)

DME Name	DME ID	UniProt ID	MOA	REF
Serum paraoxonase/arylesterase 1 (PON1)^{Main DME}	DESDN74	PON1_HUMAN	Substrate	[2]

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References

1	URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 5462).
2	Human serum paraoxonase (PON1) isozymes Q and R hydrolyze lactones and cyclic carbonate esters. Drug Metab Dispos. 2000 Nov;28(11):1335-42.
3	Identification of esterase involved in the metabolism of two corticosteroid soft drugs. Biochem Pharmacol. 2017 Mar 1;127:82-89.
4	Paraoxonases-1, -2 and -3: what are their functions? Chem Biol Interact. 2016 Nov 25;259(Pt B):51-62.