Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMDUC2X)

Drug Name

S-benzyl phenylmethanesulfinothioate Drug Info

Synonyms

S-benzyl phenylmethanesulfinothioate; CHEMBL1224167; 16302-98-0; S-benzyl phenylmethanethiosulfinate; Benzenemethanesulfinothioic acid, S-(phenylmethyl) ester; petivericin; benzylsulfinylsulfanylmethylbenzene; Benzyl(benzylthio) sulfoxide; SCHEMBL10391146; CTK0E6161; DTXSID90437280; BDBM50325648; S-benzyl phenylmethanesulfinothioate (Petivericin)

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

Cross-matching ID

PubChem CID: 10244468
CAS Number: CAS 16302-98-0
TTD Drug ID: DMDUC2X

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Approved Drug(s)

Investigative Drug(s)

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Drug(s) Targeting Cysteine protease (CYP)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
MELARSOPROL	DMGUZ0W	Trypanosomiasis	1D51-1F53	Approved	[2]
K-777	DMIFCMW	Discovery agent	N.A.	Investigative	[3]
N-methyl-Pip-F-homoF-vinyl sulfonyl phenyl (N-methyl-Pip-F-hF-VS phi)	DMDAN0K	Discovery agent	N.A.	Investigative	[4]
S-hexyl hexane-1-sulfinothioate	DMODS9A	Discovery agent	N.A.	Investigative	[1]
S-isopentyl 3-methylbutane-1-sulfinothioate	DM1NXFL	Discovery agent	N.A.	Investigative	[1]
S-propyl propane-1-sulfinothioate	DMFTLY9	Discovery agent	N.A.	Investigative	[1]
ALLICIN	DMSOJ6H	Discovery agent	N.A.	Investigative	[1]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

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Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Cysteine protease (CYP)	TT2SUAQ	NOUNIPROTAC	Inhibitor	[1]

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References

1	Allicin and derivates are cysteine protease inhibitors with antiparasitic activity. Bioorg Med Chem Lett. 2010 Sep 15;20(18):5541-3.
2	On-bead screening of a combinatorial fumaric acid derived peptide library yields antiplasmodial cysteine protease inhibitors with unusual peptide s... J Med Chem. 2009 Sep 24;52(18):5662-72.
3	Novel non-peptidic vinylsulfones targeting the S2 and S3 subsites of parasite cysteine proteases. Bioorg Med Chem Lett. 2009 Nov 1;19(21):6218-21.
4	A cysteine protease inhibitor cures Chagas' disease in an immunodeficient-mouse model of infection. Antimicrob Agents Chemother. 2007 Nov;51(11):3932-9.