Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMDWZGJ)

Drug Name

5-hydroxy-L-tryptophan Drug Info

Synonyms

5-hydroxytryptophan

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

Cross-matching ID

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Investigative Drug(s)

Discontinued Drug(s)

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Drug(s) Targeting Solute carrier family 36 member 1 (SLC36A1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
indole-3-propionic acid	DMF0VAG	Discovery agent	N.A.	Investigative	[2]
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Drug(s) Targeting Solute carrier family 36 member 2 (SLC36A2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
NOX-200	DM78P4X	Rheumatoid arthritis	FA20	Terminated	[3]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

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Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Solute carrier family 36 member 1 (SLC36A1)	TTUYIZW	S36A1_HUMAN	Inhibitor	[2]
Solute carrier family 36 member 2 (SLC36A2)	TT5U0XA	S36A2_HUMAN	Inhibitor	[3]

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References

1	URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 4671).
2	Serotonin, L-tryptophan, and tryptamine are effective inhibitors of the amino acid transport system PAT1. FASEB J. 2005 Sep;19(11):1468-73.
3	Amino acid derivatives are substrates or non-transported inhibitors of the amino acid transporter PAT2 (slc36a2). Biochim Biophys Acta. 2011 Jan;1808(1):260-70.