Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMDYT6P)

• Drug Name: PMID25742366C14b Drug Info
• Synonyms: GTPL8684

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

• Cross-matching ID:
  PubChem CID: 91827386
  TTD Drug ID: DMDYT6P

Molecule-Related Drug Atlas

Drug(s) Targeting Peptidyl arginine deiminase type III (PADI3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
PMID24440480C3	DMHQK54	Discovery agent	N.A.	Investigative	[2]
streptonigrin	DM0HOEA	Discovery agent	N.A.	Investigative	[3]
Cl-amidine	DMRV89X	Discovery agent	N.A.	Investigative	[1]

Drug(s) Targeting Peptidyl arginine deiminase type IV (PADI4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
PMID24440480C3	DMHQK54	Discovery agent	N.A.	Investigative	[2]
streptonigrin	DM0HOEA	Discovery agent	N.A.	Investigative	[4]
Cl-amidine	DMRV89X	Discovery agent	N.A.	Investigative	[1]

Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Peptidyl arginine deiminase type III (PADI3)	TTSCHFW	PADI3_HUMAN	Inhibitor	[1]
Peptidyl arginine deiminase type IV (PADI4)	TTQHAXM	PADI4_HUMAN	Inhibitor	[1]

References

• [1] Identification of multiple structurally distinct, nonpeptidic small molecule inhibitors of protein arginine deiminase 3 using a substrate-based fragment method. J Am Chem Soc. 2015 Mar 18;137(10):3616-21.
• [2] Insights into the mechanism of streptonigrin-induced protein arginine deiminase inactivation. Bioorg Med Chem. 2014 Feb 15;22(4):1362-9.
• [3] URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 2878).
• [4] A fluopol-ABPP HTS assay to identify PAD inhibitors. Chem Commun (Camb). 2010 Oct 14;46(38):7175-7.