Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMDZE3B)

Drug Name

HGT-1111 Drug Info

Synonyms

Metazym; M-0001; Recombinant arylsulfatase A (lysosomal storage disease), Shire; Recombinant arylsulfatase A (lysosomal storage disease), Zymenex; Recombinant arylsulfatase A (metachromatic leukodystrophy), Shire; Lysosomal arylsulfatase A replacement therapy (FGE, metachromatic leukodystrophy), Shire; Lysosomal asa replacement therapy (FGE, metachromatic leukodystrophy), Shire

Indication

Disease Entry	ICD 11	Status	REF
Metachromatic leukodystrophy	5C56.02	Phase 2	[1]

Cross-matching ID

TTD Drug ID: DMDZE3B

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Approved Drug(s)

Download the Complete Related Drug List

Drug(s) Targeting Cerebroside-sulfatase (ARSA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
OTL-200	DMQNI7O	Metachromatic leukodystrophy	5C56.02	Approved	[2]
------------------------------------------------------------------------------------

Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Cerebroside-sulfatase (ARSA)	TTYQANR	ARSA_HUMAN	Modulator	[1]

------------------------------------------------------------------------------------

References

1	ClinicalTrials.gov (NCT00681811) Open-Label Extension Study of Recombinant Human Arylsulfatase A (HGT-1111) in Late Infantile MLD. U.S. National Institutes of Health.
2	Clinical pipeline report, company report or official report of Orchard Therapeutics.