Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DME09J2)

Drug Name

2-(3-Methyl-3H-imidazol-4-yl)-ethylamine Drug Info

Synonyms

3-Methylhistamine; Tau-methylhistamine; 644-42-8; Imidazole, 5-(2-aminoethyl)-1-methyl-; L-histamine deriv. 1; 2-(1-methyl-1H-imidazol-5-yl)ethan-1-amine; 1H-Imidazole-5-ethanamine, 1-methyl-; CHEMBL14722; 2-(1-methyl-1H-imidazol-5-yl)ethanamine; CPAGZVLINCPJEH-UHFFFAOYSA-N; 2-(3-methylimidazol-4-yl)ethanamine; 3-Methyl Histamine Dihydrochloride; (r)-a-methylhistamine; AC1Q4WNL; SCHEMBL946729; BDBM7967; AC1L2C25; CTK5C1256; DTXSID10214651; ZINC403074; AKOS006340201; 1H-Imidazole-5-ethanamine,1-methyl-

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

Cross-matching ID

PubChem CID: 69520
CAS Number: CAS 644-42-8
TTD Drug ID: DME09J2

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Approved Drug(s)

Clinical Trial Drug(s)

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Drug(s) Targeting Histamine H3 receptor (H3R)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Pitolisant	DM8RFNJ	Excessive daytime sleepiness	MG42	Approved	[2]
SUVN-G3031	DM3BO8G	Cognitive impairment	6D71	Phase 3	[3]
JNJ-17216498	DM1GRCU	Narcolepsy	7A20	Phase 2	[4]
GSK239512	DMBJMZC	Alzheimer disease	8A20	Phase 2	[5]
JNJ-39220675	DM0WY3H	Alcohol dependence	6C40.2	Phase 2	[6]
AZD-5213	DMOZ04X	Alzheimer disease	8A20	Phase 2	[7]
Bavisant	DM6CVZ5	Attention deficit hyperactivity disorder	6A05.Z	Phase 2	[8]
ABT-288	DM7X54F	Alzheimer disease	8A20	Phase 2	[9]
SAR-110894	DMCLEXM	Alzheimer disease	8A20	Phase 2	[7]
ABT-652	DMLEO2Z	Diabetic neuropathy	8C0Z	Phase 2	[10]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

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Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Histamine H3 receptor (H3R)	TT9JNIC	HRH3_HUMAN	Inhibitor	[1]

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References

1	New acetylene based histamine H3 receptor antagonists derived from the marine natural product verongamine. Bioorg Med Chem Lett. 1998 May 19;8(10):1133-8.
2	Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health Human Services. 2019
3	Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
4	Acute wake-promoting actions of JNJ-5207852, a novel, diamine-based H3 antagonist. Br J Pharmacol. 2004 Nov;143(5):649-61.
5	Clinical pipeline report, company report or official report of GlaxoSmithKline (2009).
6	JNJ-39220675, a novel selective histamine H3 receptor antagonist, reduces the abuse-related effects of alcohol in rats. Psychopharmacology (Berl). 2011 Apr;214(4):829-41.
7	SAR110894, a potent histamine H receptor antagonist, displays procognitive effects in rodents. Pharmacol Biochem Behav. 2012 Aug;102(2):203-14.
8	Randomized clinical study of a histamine H3 receptor antagonist for the treatment of adults with attention-deficit hyperactivity disorder. CNS Drugs. 2012 May 1;26(5):421-34.
9	A randomized study of H3 antagonist ABT-288 in mild-to-moderate Alzheimer's dementia.J Alzheimers Dis.2014;42(3):959-71.
10	Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800032225)