Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DME5IJQ)

Drug Name

CR-5259 Drug Info

Synonyms

CR-4144 series; CR-4152 series; CR-4153 series; CR-4167 series; Aggrecanase (ADAMTS-4 and 5) inhibitors (osteoarthritis),Rottapharm Madaus

Indication

Disease Entry	ICD 11	Status	REF
Osteoarthritis	FA00-FA05	Investigative	[1]

Cross-matching ID

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Clinical Trial Drug(s)

Discontinued Drug(s)

Investigative Drug(s)

Download the Complete Related Drug List

Drug(s) Targeting Aggrecanase (ADAMTS5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
AGG-523	DMVMIBY	Osteoarthritis	FA00-FA05	Phase 1	[2]
SC-44463	DMBPNKT	N. A.	N. A.	Terminated	[3]
PMID21536437C15c	DM2R94W	Discovery agent	N.A.	Investigative	[4]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

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Drug Therapeutic Target (DTT)

References

1	URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 1677).
2	Elevated aggrecanase activity in a rat model of joint injury is attenuated by an aggrecanase specific inhibitor. Osteoarthritis Cartilage. 2011 Mar;19(3):315-23.
3	Design and synthesis of a series of (2R)-N(4)-hydroxy-2-(3-hydroxybenzyl)-N(1)- [(1S,2R)-2-hydroxy-2,3-dihydro-1H-inden-1-yl]butanediamide derivati... J Med Chem. 2001 Oct 11;44(21):3347-50.
4	Orally active achiral N-hydroxyformamide inhibitors of ADAM-TS4 (aggrecanase-1) and ADAM-TS5 (aggrecanase-2) for the treatment of osteoarthritis. Bioorg Med Chem Lett. 2011 Jun 1;21(11):3301-6.