Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DME617W)

Drug Name

Neucardin Drug Info

Synonyms

Human neuregulin-1 recombinant peptide fragment (injectable, heart failure/cardiomyopathy), Zensun; RhNRG-1 (injectable, heartfailure/cardiomyopathy), Zensun

Indication

Disease Entry	ICD 11	Status	REF
Heart failure	BD10-BD13	Phase 3	[1]
Chronic heart failure	BD1Z	Phase 2	[2]

Cross-matching ID

TTD Drug ID: DME617W

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Clinical Trial Drug(s)

Download the Complete Related Drug List

Drug(s) Targeting Pro-neuregulin-1 (Pro-NRG1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
GGF	DMVWYOU	Congestive heart failure	BD10	Phase 1b	[4]
GGF-2	DMDMPKC	Heart failure	BD10-BD13	Phase 1	[3]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Pro-neuregulin-1 (Pro-NRG1)	TTEH395	NRG1_HUMAN	Modulator	[3]

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References

1	ClinicalTrials.gov (NCT01214096) Clinical Trial to Evaluate the Efficacy and Safety of Recombinant Human Neuregulin-1 for Subcutaneous Administration in Patients With Chronic Systolic Heart Failure. U.S. National Institutes of Health.
2	Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
3	Interpreting expression profiles of cancers by genome-wide survey of breadth of expression in normal tissues. Genomics 2005 Aug;86(2):127-41.
4	Glial growth factor/neuregulin inhibits Schwann cell myelination and induces demyelination. J Cell Biol. 2001 Mar 19;152(6):1289-99.