Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DME65H8)

Drug Name

K185 Drug Info

Synonyms

K-185; K 185

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

Cross-matching ID

PubChem CID: 5311198
CAS Number: CAS 32223-82-8
TTD Drug ID: DME65H8

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Approved Drug(s)

Clinical Trial Drug(s)

Discontinued Drug(s)

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Drug(s) Targeting Melatonin receptor type 1A (MTNR1A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Melatonin	DMKWFBT	Depression	6A70-6A7Z	Approved	[3]
Ramelteon	DM7IW9J	Insomnia	7A00-7A0Z	Approved	[4]
Tasimelteon	DMLOQ1V	Insomnia	7A00-7A0Z	Approved	[5]
Neu-P11	DMIQDFW	Alzheimer disease	8A20	Phase 2	[6]
LY-156735	DM5IX9M	Anxiety disorder	6B00-6B0Z	Phase 2	[7]
Agomelatine	DMXYA5K	Major depressive disorder	6A70.3	Withdrawn from market	[8]
Luzindole	DMXRJQV	Sleep-wake disorder	7A00-7B2Z	Terminated	[9]
S-20928	DMQDWMJ	Sleep-wake disorder	7A00-7B2Z	Terminated	[10]
GR-133347	DMNRJA0	Anxiety disorder	6B00-6B0Z	Terminated	[11]
GR-131663	DMKAGLV	Anxiety disorder	6B00-6B0Z	Terminated	[12]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

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Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Melatonin receptor type 1A (MTNR1A)	TT0WAIE	MTR1A_HUMAN	Antagonist	[2]

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References

1	URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 1359).
2	Mapping the melatonin receptor. 6. Melatonin agonists and antagonists derived from 6H-isoindolo[2,1-a]indoles, 5,6-dihydroindolo[2,1-a]isoquinolines, and 6,7-dihydro-5H-benzo[c]azepino[2,1-a]indoles.J Med Chem. 2000 Mar 23;43(6):1050-61.
3	The human MT1 melatonin receptor stimulates cAMP production in the human neuroblastoma cell line SH-SY5Y cells via a calcium-calmodulin signal transduction pathway. J Neuroendocrinol. 2005 Mar;17(3):170-8.
4	MT1 and MT2 melatonin receptors: ligands, models, oligomers, and therapeutic potential. J Med Chem. 2014 Apr 24;57(8):3161-85.
5	URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 7393).
6	URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 288).
7	Melatonin and sleep in aging population. Exp Gerontol. 2005 Dec;40(12):911-25.
8	Melatonin receptor agonists: SAR and applications to the treatment of sleep-wake disorders. Curr Top Med Chem. 2008;8(11):954-68.
9	Luzindole (N-0774): a novel melatonin receptor antagonist. J Pharmacol Exp Ther. 1988 Sep;246(3):902-10.
10	Effects of two melatonin analogues, S-20098 and S-20928, on melatonin receptors in the pars tuberalis of the rat. J Pineal Res. 1998 Oct;25(3):172-6.
11	US patent application no. 5,151,446, Substituted 2-amidotetralins as melatonin agonists and antagonists.
12	Novel non-indolic melatonin receptor agonists differentially entrain endogenous melatonin rhythm and increase its amplitude. Eur J Pharmacol. 1999 Oct 15;382(3):157-66.