Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DME6QH1)

Drug Name

AMG 557 Drug Info

Indication

Disease Entry	ICD 11	Status	REF
Sjogren syndrome	4A43.20	Phase 2	[1]
Systemic lupus erythematosus	4A40.0	Phase 2	[2]

Cross-matching ID

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Clinical Trial Drug(s)

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Drug(s) Targeting B7-related protein 1 (B7RP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
AMG 570	DMY1XJH	Systemic lupus erythematosus	4A40.0	Phase 2	[4]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

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Drug Therapeutic Target (DTT)

References

1	Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
2	ClinicalTrials.gov (NCT02334306) A Phase 2a, Randomized, Placebo Controlled, Study to Evaluate the Safety and Efficacy of AMG 557/MEDI5872 in Primary Sj ren's Syndrome. U.S. National Institutes of Health.
3	Administration Of AMG 557, A Human Anti-B7RP-1 (ICOSL) Antibody, Leads To The Selective Inhibition Of Anti-KLH IgG Responses In Subjects With SLE: Results Of A Phase 1 Randomized, Double-Blind, Placebo-Controlled, Sequential, Rising, Multiple-Dose Study. San Diego, CA October 25-30, 2013
4	Development of an ICOSL and BAFF bispecific inhibitor AMG 570 for systemic lupus erythematosus treatment. Clin Exp Rheumatol. Nov-Dec 2019;37(6):906-914.