Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DME6X27)

• Drug Name: UR-63325 Drug Info
• Synonyms: DP-1; Histamine H4 antagonist (allergic rhinitis, asthma), Palau

Indication

Disease Entry	ICD 11	Status	REF
Allergic rhinitis	CA08.0	Phase 2	[1]

• Cross-matching ID:
  PubChem CID: 42603186
  TTD Drug ID: DME6X27

Molecule-Related Drug Atlas

Drug(s) Targeting Histamine H4 receptor (H4R)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
PF-3893787	DMC2FAL	Atopic dermatitis	EA80	Phase 2	[3]
JNJ-38518168	DM9UMIO	Plaque psoriasis	EA90.0	Phase 2	[4]
Thioperamide	DM8S593	Cognitive impairment	6D71	Terminated	[5]
2-(2-(4-tert-Butylphenylthio)ethyl)-1H-imidazole	DMZVBPG	Discovery agent	N.A.	Investigative	[6]
impromidine	DMTDRPM	Discovery agent	N.A.	Investigative	[7]
burimamide	DMZ2VYG	Discovery agent	N.A.	Investigative	[8]
Imetit	DMMJ6NS	Discovery agent	N.A.	Investigative	[9]
[125I]iodophenpropit	DMN4ABU	Discovery agent	N.A.	Investigative	[10]
(R)-alpha-methylhistamine	DMKAW4P	Discovery agent	N.A.	Investigative	[11]
N-[3H]alpha-methylhistamine	DMWDCV1	Discovery agent	N.A.	Investigative	[12]

Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Histamine H4 receptor (H4R)	TTXJ178	HRH4_HUMAN	Antagonist	[2]

References

• [1] ClinicalTrials.gov (NCT01260753) Proof of Activity Study of UR-63325 in Allergic Rhinitis Induced by Nasal Challenge. U.S. National Institutes of Health.
• [2] Azines as histamine H4 receptor antagonists. Front Biosci (Schol Ed). 2012 Jan 1;4:967-87.
• [3] Challenges of drug discovery in novel target space. The discovery and evaluation of PF-3893787: a novel histamine H4 receptor antagonist. Bioorg Med Chem Lett. 2011 Nov 1;21(21):6596-602.
• [4] The histamine H4 receptor: from orphan to the clinic. Front Pharmacol. 2015; 6: 65.
• [5] Role of histamine in short- and long-term effects of methamphetamine on the developing mouse brain. J Neurochem. 2008 Nov;107(4):976-86.
• [6] Synthesis and structure-activity relationships of N-aryl-piperidine derivatives as potent (partial) agonists for human histamine H3 receptor. Bioorg Med Chem. 2010 Jul 15;18(14):5441-8.
• [7] Evaluation of histamine H1-, H2-, and H3-receptor ligands at the human histamine H4 receptor: identification of 4-methylhistamine as the first pote... J Pharmacol Exp Ther. 2005 Sep;314(3):1310-21.
• [8] Comparison of human, mouse, rat, and guinea pig histamine H4 receptors reveals substantial pharmacological species variation. J Pharmacol Exp Ther. 2001 Oct;299(1):121-30.
• [9] Histamine excites neonatal rat sympathetic preganglionic neurons in vitro via activation of H1 receptors. J Neurophysiol. 2006 Apr;95(4):2492-500.
• [10] Discovery of novel human histamine H4 receptor ligands by large-scale structure-based virtual screening. J Med Chem. 2008 Jun 12;51(11):3145-53.
• [11] Cloning and pharmacological characterization of a fourth histamine receptor (H(4)) expressed in bone marrow. Mol Pharmacol. 2001 Mar;59(3):420-6.
• [12] Histamine induces cytoskeletal changes in human eosinophils via the H(4) receptor. Br J Pharmacol. 2003 Nov;140(6):1117-27.