Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMEUGZL)

Drug Name

Legumain-cleavable doxorubicin prodrugs Drug Info

Synonyms

Legubicin; LEG-2; LEG-3; Legumain-cleavable doxorubicin prodrugs (cancer); Legumain-cleavabledoxorubicin prodrugs (cancer), Affinity Pharmaceuticals

Indication

Disease Entry	ICD 11	Status	REF
Solid tumour/cancer	2A00-2F9Z	Phase 2/3	[1]

Cross-matching ID

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Investigative Drug(s)

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Drug(s) Targeting Legumain (LGMN)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
PMID24775305C7u	DMDMU01	Discovery agent	N.A.	Investigative	[3]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

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Drug Therapeutic Target (DTT)

References

1	ClinicalTrials.gov (NCT01442636) Drug Eluting Stents In The Critically Ischemic Lower Leg 2. U.S. National Institutes of Health.
2	URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 2380).
3	P3 SAR exploration of biphenyl carbamate based Legumain inhibitors. Bioorg Med Chem Lett. 2014 Jun 1;24(11):2521-4.