Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMF1X5P)

Drug Name
Proflavine Drug Info
Synonyms
PRL; Proflavin; Proflavina; Proflavinum; Profura; Progarmed; Isoflav base; Proflavine [INN]; Proflavine hemisulfate; Proflavina [INN-Spanish]; Proflavine Hemi-Sulfate; Proflavinum [INN-Latin]; AE-562/12222295; Acridine-3,6-diamine; 2,8-Diaminoacridine; 2,8-Diaminoacridine (European); 2,8-Diaminoacridinium; 3,6-ACRIDINEDIAMINE; 3,6-Acridinediamine hydrochloride; 3,6-Diamino-acridinium; 3,6-Diaminoacridine; 3,6-Diaminoacridine sulfate; 3,6-Diaminoacridinium; 3,7-Diamino-5-azaanthracene
Indication
Disease Entry ICD 11 Status REF
Sepsis 1G40-1G41 Approved [1]
Therapeutic Class
Antiinfective Agents
Cross-matching ID
PubChem CID
7099
ChEBI ID
CHEMBL55400
CAS Number
CAS 92-62-6
TTD Drug ID
DMF1X5P

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
Drug Status:
Approved Drug(s)
Clinical Trial Drug(s)
Download the Complete Related Drug List
Drug(s) Targeting Bacterial Deoxyribonucleic acid (Bact DNA)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Metronidazole DMTIVEN Abscess Approved [3]
Nitrofurantoin DM7PQIK Urinary tract infection GC08 Approved [4]
Clofazimine DMEBOFW Crohn disease DD70 Approved [5]
Hydroxystilbamidine Isethionate DMR5QS6 Blastomycosis 1F22 Approved [6]
Furazolidone DM3P6V7 Diarrhea ME05.1 Approved [7]
MGB-BP-3 DMPBTVK Clostridium infection 1A04 Phase 2 [8]
⏷ Show the Full List of 6 Drug(s)

Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas
Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Bacterial Deoxyribonucleic acid (Bact DNA) TTS1W4A NOUNIPROTAC Binder [2]

References

1 Drug information of Proflavine, 2008. eduDrugs.
2 Interaction of small molecules with double-stranded RNA: spectroscopic, viscometric, and calorimetric study of hoechst and proflavine binding to PolyCG structures. DNA Cell Biol. 2009 Apr;28(4):209-19.
3 DNA breakage due to metronidazole treatment. Mutat Res. 2001 Jul 1;478(1-2):153-8.
4 On the nature of the adaptive response induced by mitomycin C in Vibrio cholerae OGAWA 154 cells. Biochem Biophys Res Commun. 1996 Mar 27;220(3):509-14.
5 The mode of action of clofazimine DNA binding studies. Int J Lepr Other Mycobact Dis. 1976 Jan-Jun;44(1-2):133-4.
6 Interaction between hydroxystilbamidine and DNA. I. Binding isotherms and thermodynamics of the association. Biochim Biophys Acta. 1975 Sep 12;407(1):24-42.
7 Interaction of furazolidone with DNA. Biochim Biophys Acta. 1975 Aug 21;402(2):161-5.
8 Clinical pipeline report, company report or official report of MGB Biopharma.